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- W2217202005 abstract "TAS-102 is a new oral anti-tumor drug, composed of a thymidine-based nucleoside analog (trifluridine: FTD) and a thymidine phosphorylase inhibitor (tipiracil hydrochloride: TPI). TAS-102 has been shown to significantly improve overall survival and progression-free survival in patients with refractory metastatic colorectal cancer (mCRC) in placebo-controlled randomized phase II and III trials. The current review summarizes mechanisms of action, pharmacokinetics/dynamics and preclinical and clinical data of TAS-102 in colorectal cancer. TAS-102 is a new salvage-line treatment option for patients with mCRC. TAS-102 is well tolerated and has great potential in future clinical drug combination therapies." @default.
- W2217202005 created "2016-06-24" @default.
- W2217202005 creator A5004189669 @default.
- W2217202005 creator A5047981191 @default.
- W2217202005 creator A5066487010 @default.
- W2217202005 date "2016-01-22" @default.
- W2217202005 modified "2023-10-16" @default.
- W2217202005 title "A novel antimetabolite: TAS-102 for metastatic colorectal cancer" @default.
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- W2217202005 doi "https://doi.org/10.1586/17512433.2016.1133285" @default.
- W2217202005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7485169" @default.
- W2217202005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26677869" @default.
- W2217202005 hasPublicationYear "2016" @default.
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