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- W2217204947 endingPage "454" @default.
- W2217204947 startingPage "431" @default.
- W2217204947 abstract "Recent developments indicate that macrodomains, an ancient and diverse protein domain family, are key players in the recognition, interpretation, and turnover of ADP-ribose (ADPr) signaling. Crucial to this is the ability of macrodomains to recognize ADPr either directly, in the form of a metabolic derivative, or as a modification covalently bound to proteins. Thus, macrodomains regulate a wide variety of cellular and organismal processes, including DNA damage repair, signal transduction, and immune response. Their importance is further indicated by the fact that dysregulation or mutation of a macrodomain is associated with several diseases, including cancer, developmental defects, and neurodegeneration. In this review, we summarize the current insights into macrodomain evolution and how this evolution influenced their structural and functional diversification. We highlight some aspects of macrodomain roles in pathobiology as well as their emerging potential as therapeutic targets." @default.
- W2217204947 created "2016-06-24" @default.
- W2217204947 creator A5002464964 @default.
- W2217204947 creator A5021767059 @default.
- W2217204947 creator A5053318118 @default.
- W2217204947 date "2016-06-02" @default.
- W2217204947 modified "2023-10-10" @default.
- W2217204947 title "Macrodomains: Structure, Function, Evolution, and Catalytic Activities" @default.
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