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• W2217250698 abstract "The passage of time produces changes in both the behavior and the brains of organisms. For most psychologists and neuroscientists, brain-behavior relationships are studied at a single point in time. Learning and memory experiments carried out with one age group provide a snapshot of the organism. However, the passage of time adds an additional dimension that can provide insights about basic mechanisms of learning and memory. For example, Carol Barnes found age-related impairments in maze learning in rodents, and these results led her to study hippocampal place cells in older rats and make significant contributions to knowledge about spatial encoding (Barnes, Suster, Shen & McNaughton, 1997). It was the knowledge that eyeblink conditioning was impaired in normal aging that made this well-characterized model attractive for the investigation of neurobiological substrates of age-related memory impairment. Indeed, Richard F. Thompson suggested that the model system of eyeblink classical conditioning might be “the Rosetta stone for brain substrates of agerelated deficits in learning and memory,” (Thompson, 1988, p. 547). Aging is most typically associated with declines in functioning, both neural and behavioral. However, individual organisms age at different rates. One organism may show a steady decline in functioning while another shows only slight changes over the years. An important goal towards an understanding of the aging process is to determine how changes in neural structures impact on behavior. As such, tasks that engage well-defined neural substrates are particularly valuable. Eyeblink classical conditioning is such a task. In this chapter, we will review research that suggests that age-associated changes in two neural substrates that have been demonstrated to be critical for eyeblink classical conditioning, the hippocampus and the cerebellum, are responsible for age-associated declines in conditioning. These findings have led to the use of eyeblink classical conditioning as a preclinical test for potential cognitionenhancing drugs intended to reverse declines in learning and memory caused by the effects of both normal and pathological aging on the brain." @default.
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• W2217250698 date "2005-11-26" @default.
• W2217250698 modified "2023-09-25" @default.
• W2217250698 title "Eyeblink Classical Conditioning in Aging Animals" @default.
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• W2217250698 doi "https://doi.org/10.1007/0-306-46897-2_7" @default.
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