FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2217362286> ?p ?o ?g. }

• W2217362286 endingPage "2769" @default.
• W2217362286 startingPage "2753" @default.
• W2217362286 abstract "Phylogenetic analyses of molecular data require a quantitative model for how sequences evolve. Traditionally, the details of the site-specific selection that governs sequence evolution are not known a priori, making it challenging to create evolutionary models that adequately capture the heterogeneity of selection at different sites. However, recent advances in high-throughput experiments have made it possible to quantify the effects of all single mutations on gene function. I have previously shown that such high-throughput experiments can be combined with knowledge of underlying mutation rates to create a parameter-free evolutionary model that describes the phylogeny of influenza nucleoprotein far better than commonly used existing models. Here, I extend this work by showing that published experimental data on TEM-1 beta-lactamase (Firnberg E, Labonte JW, Gray JJ, Ostermeier M. 2014. A comprehensive, high-resolution map of a gene’s fitness landscape. Mol Biol Evol. 31:1581–1592) can be combined with a few mutation rate parameters to create an evolutionary model that describes beta-lactamase phylogenies much better than most common existing models. This experimentally informed evolutionary model is superior even for homologs that are substantially diverged (about 35% divergence at the protein level) from the TEM-1 parent that was the subject of the experimental study. These results suggest that experimental measurements can inform phylogenetic evolutionary models that are applicable to homologs that span a substantial range of sequence divergence." @default.
• W2217362286 created "2016-06-24" @default.
• W2217362286 creator A5091068534 @default.
• W2217362286 date "2014-07-24" @default.
• W2217362286 modified "2023-09-30" @default.
• W2217362286 title "An Experimentally Informed Evolutionary Model Improves Phylogenetic Fit to Divergent Lactamase Homologs" @default.
• W2217362286 cites W1575215071 @default.
• W2217362286 cites W1861263514 @default.
• W2217362286 cites W1966972227 @default.
• W2217362286 cites W1967055944 @default.
• W2217362286 cites W1971273325 @default.
• W2217362286 cites W1983528535 @default.
• W2217362286 cites W1986152701 @default.
• W2217362286 cites W1999721851 @default.
• W2217362286 cites W2003378333 @default.
• W2217362286 cites W2007339420 @default.
• W2217362286 cites W2008708467 @default.
• W2217362286 cites W2009596137 @default.
• W2217362286 cites W2010053735 @default.
• W2217362286 cites W2010630154 @default.
• W2217362286 cites W2010753155 @default.
• W2217362286 cites W2045112588 @default.
• W2217362286 cites W2053937911 @default.
• W2217362286 cites W2055968189 @default.
• W2217362286 cites W2056760934 @default.
• W2217362286 cites W2060425093 @default.
• W2217362286 cites W2063216803 @default.
• W2217362286 cites W2077235131 @default.
• W2217362286 cites W2080473579 @default.
• W2217362286 cites W2094223039 @default.
• W2217362286 cites W2097356092 @default.
• W2217362286 cites W2099254366 @default.
• W2217362286 cites W2101301747 @default.
• W2217362286 cites W2101846955 @default.
• W2217362286 cites W2102424972 @default.
• W2217362286 cites W2107010419 @default.
• W2217362286 cites W2111472408 @default.
• W2217362286 cites W2113557726 @default.
• W2217362286 cites W2115622704 @default.
• W2217362286 cites W2124790653 @default.
• W2217362286 cites W2126103104 @default.
• W2217362286 cites W2126371317 @default.
• W2217362286 cites W2126917299 @default.
• W2217362286 cites W2131527832 @default.
• W2217362286 cites W2132356750 @default.
• W2217362286 cites W2134352676 @default.
• W2217362286 cites W2134757533 @default.
• W2217362286 cites W2135753651 @default.
• W2217362286 cites W2137195513 @default.
• W2217362286 cites W2138178197 @default.
• W2217362286 cites W2141913814 @default.
• W2217362286 cites W2144893575 @default.
• W2217362286 cites W2147307434 @default.
• W2217362286 cites W2151887741 @default.
• W2217362286 cites W2153261051 @default.
• W2217362286 cites W2154414334 @default.
• W2217362286 cites W2158266834 @default.
• W2217362286 cites W2160364329 @default.
• W2217362286 cites W2160659074 @default.
• W2217362286 cites W2164494468 @default.
• W2217362286 cites W2168696662 @default.
• W2217362286 cites W2168749685 @default.
• W2217362286 cites W2168999925 @default.
• W2217362286 cites W2169505290 @default.
• W2217362286 doi "https://doi.org/10.1093/molbev/msu220" @default.
• W2217362286 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4166927" @default.
• W2217362286 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25063439" @default.
• W2217362286 hasPublicationYear "2014" @default.
• W2217362286 type Work @default.
• W2217362286 sameAs 2217362286 @default.
• W2217362286 citedByCount "35" @default.
• W2217362286 countsByYear W22173622862015 @default.
• W2217362286 countsByYear W22173622862016 @default.
• W2217362286 countsByYear W22173622862017 @default.
• W2217362286 countsByYear W22173622862018 @default.
• W2217362286 countsByYear W22173622862019 @default.
• W2217362286 countsByYear W22173622862020 @default.
• W2217362286 countsByYear W22173622862021 @default.
• W2217362286 countsByYear W22173622862022 @default.
• W2217362286 countsByYear W22173622862023 @default.
• W2217362286 crossrefType "journal-article" @default.
• W2217362286 hasAuthorship W2217362286A5091068534 @default.
• W2217362286 hasBestOaLocation W22173622861 @default.
• W2217362286 hasConcept C104317684 @default.
• W2217362286 hasConcept C111472728 @default.
• W2217362286 hasConcept C119857082 @default.
• W2217362286 hasConcept C138885662 @default.
• W2217362286 hasConcept C14036430 @default.
• W2217362286 hasConcept C193252679 @default.
• W2217362286 hasConcept C207390915 @default.
• W2217362286 hasConcept C41008148 @default.
• W2217362286 hasConcept C41895202 @default.
• W2217362286 hasConcept C501734568 @default.
• W2217362286 hasConcept C54355233 @default.
• W2217362286 hasConcept C70721500 @default.
• W2217362286 hasConcept C75553542 @default.
• W2217362286 hasConcept C78458016 @default.
• W2217362286 hasConcept C81917197 @default.

• next