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- W2217362462 abstract "The role of adenosine A 1 receptors (A 1 R) in reflex-evoked short-circuit current ( I sc ) indicative of chloride secretion was studied in the guinea pig colon. The A 1 R antagonist 8-cyclopentyltheophylline (CPT) enhanced reflex-evoked I sc . Adenosine deaminase and the nucleoside transport inhibitor S-(4-nitrobenzyl)-6-thioinosine enhanced and reduced reflex-induced I sc , respectively. The A 1 R agonist 2-chloro- N 6 -cyclopentyladenosine (CCPA) inhibited reflex-evoked I sc at nanomolar concentrations, and its action was antagonized by CPT. In the presence of either N-acetyl-5-hydroxytryptophyl-5-hydroxytryptophan amide to block the 5-hydroxytryptamine (5-HT)-mediated pathway or piroxicam to block the prostaglandin-mediated pathway, CCPA reduced the residual reflex-evoked I sc . CCPA reduced the response to a 5-HT pulse without affecting the tetrodotoxin-insensitive I sc responses to carbachol or forskolin. Immunoreactivity for A 1 R was detected in the membrane (10% of neurons) and cytoplasm (90% of neurons) of neural protein gene product 9.5-immunoreactive (or S-100-negative) submucosal neurons, in glia, and in the muscularis mucosa. A 1 R immunoreactivity in a majority of neurons remained elevated in the cytoplasm despite preincubation with adenosine deaminase or CPT. A 1 R immunoreactivity colocalized in synaptophysin-immunoreactive presynaptic varicose nerve terminals. The results indicate that endogenous adenosine binding to high-affinity A 1 R on submucosal neurons acts as a physiological brake to suppress reflex-evoked I sc indicative of chloride secretion." @default.
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- W2217362462 date "1999-02-01" @default.
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- W2217362462 title "Activation of neuronal adenosine A1 receptors suppresses secretory reflexes in the guinea pig colon" @default.
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- W2217362462 doi "https://doi.org/10.1152/ajpgi.1999.276.2.g451" @default.
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