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- W2217562023 abstract "The effective targeting and subsequent binding of particulate carriers to M cells in Peyer's patches of the gut is a prerequisite for the development of oral delivery systems. We have established a novel carrier system based on cell surface expression of the β1-integrin binding domain of invasins derived from Yersinia enterocolitica and Yersinia pseudotuberculosis on the yeast Saccharomyces cerevisiae. All invasin derivatives were shown to be effectively expressed on the cell surface and recombinant yeast cells showed improved binding to both human HEp-2 cells and M-like cells in vitro. Among the different derivatives tested, the integrin-binding domain of Y. enterocolitica invasin proved to be the most effective and was able to target Peyer's patches in vivo. In conclusion, cell surface-modified yeasts might provide a novel bioadhesive, eukaryotic carrier system for efficient and targeted delivery of either antigens or drugs via the oral route." @default.
- W2217562023 created "2016-06-24" @default.
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- W2217562023 date "2016-02-01" @default.
- W2217562023 modified "2023-10-03" @default.
- W2217562023 title "Surface-modified yeast cells: A novel eukaryotic carrier for oral application" @default.
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- W2217562023 doi "https://doi.org/10.1016/j.jconrel.2015.12.054" @default.
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