Matches in SemOpenAlex for { <https://semopenalex.org/work/W2217757330> ?p ?o ?g. }
- W2217757330 endingPage "100" @default.
- W2217757330 startingPage "87" @default.
- W2217757330 abstract "The integrin family of extracellular matrix receptors plays an important role in normal development, epithelial morphogenesis, angiogenesis, and in tumor progression and metastasis. Integrins cooperate with growth factor receptors to control many cellular functions including proliferation and cell survival. Integrin-mediated adhesion regulates many of the cell cycle checkpoints including activation of cyclin D/cdk4/6 complexes, expression of cyclin D genes, and regulation of levels of cyclin-dependent kinase inhibitors. In addition, integrin-mediated cell adhesion regulates apoptosis by modulating the activity of both the mitochondrial pathway and the death receptor pathways. Therefore, integrin-mediated adhesion modulates the decision of life or death. A role for tumor-matrix interactions in the acquisition of drug resistance has been reported for many cancers including breast cancer. Recent evidence suggests that integrin-mediated adhesion to the ECM may undermine the response of tumors to chemotherapeutic agents. Integrins have been shown to be readily accessible drug targets and are therefore attractive potential targets for combined modality chemotherapy." @default.
- W2217757330 created "2016-06-24" @default.
- W2217757330 creator A5049218863 @default.
- W2217757330 date "2007-01-01" @default.
- W2217757330 modified "2023-09-23" @default.
- W2217757330 title "Integrin-Mediated Adhesion: Tipping the Balance between Chemosensitivity and Chemoresistance" @default.
- W2217757330 cites W1223895533 @default.
- W2217757330 cites W1494507441 @default.
- W2217757330 cites W1525629072 @default.
- W2217757330 cites W1529267387 @default.
- W2217757330 cites W1554419184 @default.
- W2217757330 cites W1576773659 @default.
- W2217757330 cites W1593018830 @default.
- W2217757330 cites W1819766005 @default.
- W2217757330 cites W1849793110 @default.
- W2217757330 cites W1902352259 @default.
- W2217757330 cites W1911342746 @default.
- W2217757330 cites W1918156452 @default.
- W2217757330 cites W1924355940 @default.
- W2217757330 cites W1931127206 @default.
- W2217757330 cites W1964596167 @default.
- W2217757330 cites W1964997589 @default.
- W2217757330 cites W1965078913 @default.
- W2217757330 cites W1966333562 @default.
- W2217757330 cites W1968316337 @default.
- W2217757330 cites W1968490536 @default.
- W2217757330 cites W1974586741 @default.
- W2217757330 cites W1975866732 @default.
- W2217757330 cites W1977620219 @default.
- W2217757330 cites W1979504727 @default.
- W2217757330 cites W1981166298 @default.
- W2217757330 cites W1981462495 @default.
- W2217757330 cites W1982632347 @default.
- W2217757330 cites W1983075270 @default.
- W2217757330 cites W1983386156 @default.
- W2217757330 cites W1983821491 @default.
- W2217757330 cites W1985162442 @default.
- W2217757330 cites W1986531401 @default.
- W2217757330 cites W1987035130 @default.
- W2217757330 cites W1987529353 @default.
- W2217757330 cites W1988452929 @default.
- W2217757330 cites W1988479585 @default.
- W2217757330 cites W1989247542 @default.
- W2217757330 cites W1989780564 @default.
- W2217757330 cites W1991150337 @default.
- W2217757330 cites W1992772703 @default.
- W2217757330 cites W1992925170 @default.
- W2217757330 cites W1993059855 @default.
- W2217757330 cites W1995903946 @default.
- W2217757330 cites W1997121235 @default.
- W2217757330 cites W1999763927 @default.
- W2217757330 cites W2000552194 @default.
- W2217757330 cites W2002645985 @default.
- W2217757330 cites W2003006566 @default.
- W2217757330 cites W2004458717 @default.
- W2217757330 cites W2006912182 @default.
- W2217757330 cites W2007981025 @default.
- W2217757330 cites W2008130230 @default.
- W2217757330 cites W2010087461 @default.
- W2217757330 cites W2011217812 @default.
- W2217757330 cites W2015066175 @default.
- W2217757330 cites W2017386384 @default.
- W2217757330 cites W2023300542 @default.
- W2217757330 cites W2024306318 @default.
- W2217757330 cites W2025018535 @default.
- W2217757330 cites W2028936118 @default.
- W2217757330 cites W2030232022 @default.
- W2217757330 cites W2031825312 @default.
- W2217757330 cites W2032971882 @default.
- W2217757330 cites W2033245926 @default.
- W2217757330 cites W2033272151 @default.
- W2217757330 cites W2033346155 @default.
- W2217757330 cites W2034752841 @default.
- W2217757330 cites W2034842897 @default.
- W2217757330 cites W2035641694 @default.
- W2217757330 cites W2036488841 @default.
- W2217757330 cites W2041997066 @default.
- W2217757330 cites W2043117244 @default.
- W2217757330 cites W2045900823 @default.
- W2217757330 cites W2049900802 @default.
- W2217757330 cites W2049976919 @default.
- W2217757330 cites W2050108686 @default.
- W2217757330 cites W2052913796 @default.
- W2217757330 cites W2054779757 @default.
- W2217757330 cites W2055400687 @default.
- W2217757330 cites W2057570450 @default.
- W2217757330 cites W2058232950 @default.
- W2217757330 cites W2058488557 @default.
- W2217757330 cites W2058539532 @default.
- W2217757330 cites W2060136332 @default.
- W2217757330 cites W2063599502 @default.
- W2217757330 cites W2066367871 @default.
- W2217757330 cites W2067427407 @default.
- W2217757330 cites W2069299583 @default.
- W2217757330 cites W2072630322 @default.
- W2217757330 cites W2073597369 @default.
- W2217757330 cites W2073661854 @default.
- W2217757330 cites W2076921551 @default.