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- W2217757445 endingPage "14" @default.
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- W2217757445 abstract "Tumors contain a distinct small subpopulation of cells that possess stem cell-like characteristics. These cells have been called cancer stem cells (CSCs) and are thought to be responsible for anticancer drug resistance and tumor relapse after therapy. Emerging evidence indicates that CSCs share many properties, such as self-renewal and quiescence, with normal stem cells. In particular, CSCs and normal stem cells retain low levels of reactive oxygen species (ROS), which can contribute to stem cell maintenance and resistance to stressful tumor environments. Current literatures demonstrate that the activation of ataxia telangiectasia mutated (ATM) and forkhead box O3 (FoxO3) is associated with the maintenance of low ROS levels in normal stem cells such as hematopoietic stem cells. However, the importance of ROS signaling in CSC biology remains poorly understood. Recent studies demonstrate that nuclear factor-erythroid 2-related factor 2 (NRF2), a master regulator of the cellular antioxidant defense system, is involved in the maintenance of quiescence, survival, and stress resistance of CSCs. Here, we review the recent findings on the roles of NRF2 in maintenance of the redox state and multidrug resistance in CSCs, focusing on how NRF2-mediated ROS modulation influences the growth and resistance of CSCs." @default.
- W2217757445 created "2016-06-24" @default.
- W2217757445 creator A5010795472 @default.
- W2217757445 creator A5053871848 @default.
- W2217757445 creator A5083891496 @default.
- W2217757445 date "2016-01-01" @default.
- W2217757445 modified "2023-10-12" @default.
- W2217757445 title "Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance" @default.
- W2217757445 cites W1490002361 @default.
- W2217757445 cites W1505061064 @default.
- W2217757445 cites W1523693806 @default.
- W2217757445 cites W1603378617 @default.
- W2217757445 cites W1624064684 @default.
- W2217757445 cites W1642353871 @default.
- W2217757445 cites W1802480460 @default.
- W2217757445 cites W1858268805 @default.
- W2217757445 cites W1913767120 @default.
- W2217757445 cites W1917529770 @default.
- W2217757445 cites W1921143360 @default.
- W2217757445 cites W1945958863 @default.
- W2217757445 cites W1965009601 @default.
- W2217757445 cites W1965306647 @default.
- W2217757445 cites W1967108243 @default.
- W2217757445 cites W1968223412 @default.
- W2217757445 cites W1968461724 @default.
- W2217757445 cites W1970634781 @default.
- W2217757445 cites W1970949335 @default.
- W2217757445 cites W1971090593 @default.
- W2217757445 cites W1972779889 @default.
- W2217757445 cites W1972782503 @default.
- W2217757445 cites W1973070600 @default.
- W2217757445 cites W1973671455 @default.
- W2217757445 cites W1973882427 @default.
- W2217757445 cites W1974470246 @default.
- W2217757445 cites W1974546855 @default.
- W2217757445 cites W1976248697 @default.
- W2217757445 cites W1979124011 @default.
- W2217757445 cites W1979803626 @default.
- W2217757445 cites W1980932672 @default.
- W2217757445 cites W1982071626 @default.
- W2217757445 cites W1983876698 @default.
- W2217757445 cites W1986753946 @default.
- W2217757445 cites W1989528875 @default.
- W2217757445 cites W1991631628 @default.
- W2217757445 cites W1992407127 @default.
- W2217757445 cites W1992724001 @default.
- W2217757445 cites W1994133951 @default.
- W2217757445 cites W1996916774 @default.
- W2217757445 cites W1998560601 @default.
- W2217757445 cites W1999148207 @default.
- W2217757445 cites W2001544973 @default.
- W2217757445 cites W2002801265 @default.
- W2217757445 cites W2003714060 @default.
- W2217757445 cites W2003962390 @default.
- W2217757445 cites W2005709407 @default.
- W2217757445 cites W2006022385 @default.
- W2217757445 cites W2006434892 @default.
- W2217757445 cites W2008202172 @default.
- W2217757445 cites W2009640428 @default.
- W2217757445 cites W2009886857 @default.
- W2217757445 cites W2009912257 @default.
- W2217757445 cites W2011006339 @default.
- W2217757445 cites W2011074645 @default.
- W2217757445 cites W2013825275 @default.
- W2217757445 cites W2014587681 @default.
- W2217757445 cites W2016602233 @default.
- W2217757445 cites W2017275974 @default.
- W2217757445 cites W2020827871 @default.
- W2217757445 cites W2023427658 @default.
- W2217757445 cites W2024290860 @default.
- W2217757445 cites W2025801301 @default.
- W2217757445 cites W2027049002 @default.
- W2217757445 cites W2027443731 @default.
- W2217757445 cites W2028298372 @default.
- W2217757445 cites W2029022033 @default.
- W2217757445 cites W2030700131 @default.
- W2217757445 cites W2031403700 @default.
- W2217757445 cites W2031869195 @default.
- W2217757445 cites W2033910705 @default.
- W2217757445 cites W2035676834 @default.
- W2217757445 cites W2040595174 @default.
- W2217757445 cites W2041399911 @default.
- W2217757445 cites W2041647205 @default.
- W2217757445 cites W2041897873 @default.
- W2217757445 cites W2043281296 @default.
- W2217757445 cites W2045907249 @default.
- W2217757445 cites W2047122678 @default.
- W2217757445 cites W2048700223 @default.
- W2217757445 cites W2050102962 @default.
- W2217757445 cites W2050259170 @default.
- W2217757445 cites W2050300062 @default.
- W2217757445 cites W2050560941 @default.
- W2217757445 cites W2050720471 @default.
- W2217757445 cites W2051055358 @default.
- W2217757445 cites W2051309543 @default.
- W2217757445 cites W2053047691 @default.
- W2217757445 cites W2055293030 @default.
- W2217757445 cites W2056247303 @default.