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- W2217849983 abstract "Human fibrinogen chromatographed on DEAE-cellulose resolves into two components containing 85% (peak 1) and 15% (peak 2) of the total fibrinogen. Peak 1 and peak 2 differ only in the composition of their γ chains, with peak 1 containing only one type of γ chain and peak 2 containing equal amounts of γ chain and a second chain, called γ′. In an effort to explain the difference in the amount of peak 1 compared to peak 2, metabolic studies were performed with radiolabeled peak 1 and peak 2 in two normal subjects. Autologous peak 1 and peak 2 fibrinogen were pooled separately, rechromatographed, labeled with 131I and 125I, respectively, and injected simultaneously. The half-lives and fractional catabolic rates of peak 1 and peak 2 in the two normal subjects were almost identical. To determine whether one peak might be a metabolic product of the other, plasma or fibrinogen samples purified from plasma obtained 2 and 6 days after infusion of the radiolabeled proteins were chromatographed on DEAE-cellulose. 131I radioactivity eluted only in peak 1 and 125I radioactivity eluted exclusively in peak 2. These studies demonstrate that the difference in concentration between peak 1 and peak 2 is not due to a difference in their catabolic rates and that there is no metabolic interconversion between these two peaks. Our data, together with recent evidence, suggest that the γ/γ′ heterogeneity originates from a postsynthetic modification of the fibrinogen molecule prior to its secretion into the peripheral circulation." @default.
- W2217849983 created "2016-06-24" @default.
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- W2217849983 date "1980-09-01" @default.
- W2217849983 modified "2023-10-18" @default.
- W2217849983 title "Metabolic studies on human fibrinogen gamma/gamma' chain heterogeneity" @default.
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- W2217849983 doi "https://doi.org/10.1182/blood.v56.3.417.417" @default.
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