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• W2218156738 abstract "Background and Aims: Colorectal cancer is the third most common cancer and the second most common cause of cancer death among Americans. Colonoscopic screening holds the potential to significantly reduce the amount of colorectal cancer death; however, the procedure is invasive and carries the risk of complications. This study aims to evaluate various patient characteristics that might predict both clinically significant findings and complications from colonoscopy. Methods: A cohort study following over 20,000 patients estimated the risk of serious complications within 30 days of colonoscopy. The present study utilizes those from that cohort with indication of screening or surveillance colonoscopy. Multivariate logistic regression models were constructed for two outcomes: (1) serious complication related to colonoscopy and (2) neoplasia (polyp or other mass) greater than 9 mm. The number needed to endoscope (NNE) in order to observe one instance of each outcome was estimated based on results from the multivariate logistic regression models. Results: Data from 21,302 participants were included in the present analysis. Sixty-eight participants experienced serious adverse events (0.31%), while 1866 had one or more polyps or other masses of size greater than 9 mm found on their exam (8.76%). Peri-procedural anticoagulation therapy was a significant risk factor for complication. Statistically significant predictors for neoplasia over 9 mm included male gender, increased patient age, ASA class of II or greater, and prior positive screening test as indication for exam. Among adults under 65, it would require an estimated 509 colonoscopies among males 607 among females before expecting to see 1 serious complication, compared to 332 for males older than 74 and 396 for similarly aged females. Use of anticoagulants appears to markedly increase risk of" @default.
• W2218156738 created "2016-06-24" @default.
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• W2218156738 date "2011-01-01" @default.
• W2218156738 modified "2023-09-23" @default.
• W2218156738 title "Estimates of complications and clinically significant findings in screening and surveillance colonoscopy" @default.
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• W2218156738 doi "https://doi.org/10.6083/m42v2d34" @default.
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