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- W2218171010 abstract "Background: Early menarche increases breast cancer risk but, aside from weight, information on its determinants is limited.Methods: Age at menarche data were collected retrospectively by questionnaire from 81 606 women aged 16–98, resident in the UK and participating in the Breakthrough Generations Study.Results: Menarche occurred earlier in women who had a low birthweight (Ptrend<0.001), were singletons (P<0.001), had prenatal exposure to pre-eclampsia (P<0.001) or maternal smoking (P=0.01), were not breastfed (Ptrend=0.03), were non-white (P<0.001), were heavy (Ptrend<0.001) or tall (Ptrend<0.001) compared with their peers at age 7 and exercised little as a child (Ptrend<0.001). Menarcheal age increased with number of siblings (P<0.001) independently of birth order, and had an inverse association with birth order after adjustment for sibship size (P<0.001). In a multivariate model, birthweight, ethnicity, weight, height, exercise, sibship size and birth order remained significant, and maternal age at birth became significant (positive association, P<0.001).Conclusion: Age at menarche was influenced by both pre- and post-natal factors, and these factors may affect breast cancer risk through this route." @default.
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- W2218171010 date "2010-01-01" @default.
- W2218171010 modified "2023-09-26" @default.
- W2218171010 title "Determinants of age at menarche in the United Kingdom: analyses from the Breakthrough Generations Study" @default.
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