FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2218454083> ?p ?o ?g. }

• W2218454083 endingPage "e0128582" @default.
• W2218454083 startingPage "e0128582" @default.
• W2218454083 abstract "Background Fructose, unlike glucose, promotes feeding behavior in rodents and its ingestion exerts differential effects in the human brain. However, plasma fructose is typically 1/1000th of glucose levels and it is unclear to what extent fructose crosses the blood-brain barrier. We investigated whether local endogenous central nervous system (CNS) fructose production from glucose via the polyol pathway (glucose→sorbitol→fructose) contributes to brain exposure to fructose. Methods In this observational study, fasting glucose, sorbitol and fructose concentrations were measured using gas-chromatography-liquid mass spectroscopy in cerebrospinal fluid (CSF), maternal plasma, and venous cord blood collected from 25 pregnant women (6 lean, 10 overweight/obese, and 9 T2DM/gestational DM) undergoing spinal anesthesia and elective cesarean section. Results As expected, CSF glucose was ~60% of plasma glucose levels. In contrast, fructose was nearly 20-fold higher in CSF than in plasma (p < 0.001), and CSF sorbitol was ~9-times higher than plasma levels (p < 0.001). Moreover, CSF fructose correlated positively with CSF glucose (ρ 0.45, p = 0.02) and sorbitol levels (ρ 0.75, p < 0.001). Cord blood sorbitol was also ~7-fold higher than maternal plasma sorbitol levels (p = 0.001). There were no differences in plasma, CSF, and cord blood glucose, fructose, or sorbitol levels between groups. Conclusions These data raise the possibility that fructose may be produced endogenously in the human brain and that the effects of fructose in the human brain and placenta may extend beyond its dietary consumption." @default.
• W2218454083 created "2016-06-24" @default.
• W2218454083 creator A5001229026 @default.
• W2218454083 creator A5008863193 @default.
• W2218454083 creator A5030702863 @default.
• W2218454083 creator A5033382787 @default.
• W2218454083 creator A5051779260 @default.
• W2218454083 creator A5052065929 @default.
• W2218454083 creator A5055158616 @default.
• W2218454083 creator A5080355318 @default.
• W2218454083 date "2015-06-02" @default.
• W2218454083 modified "2023-10-18" @default.
• W2218454083 title "Fructose Levels Are Markedly Elevated in Cerebrospinal Fluid Compared to Plasma in Pregnant Women" @default.
• W2218454083 cites W1804813305 @default.
• W2218454083 cites W1969488647 @default.
• W2218454083 cites W1971149837 @default.
• W2218454083 cites W1972638083 @default.
• W2218454083 cites W1973558885 @default.
• W2218454083 cites W1983754683 @default.
• W2218454083 cites W1988204362 @default.
• W2218454083 cites W1995592782 @default.
• W2218454083 cites W1995797193 @default.
• W2218454083 cites W1996424575 @default.
• W2218454083 cites W1997881520 @default.
• W2218454083 cites W2004454616 @default.
• W2218454083 cites W2006447143 @default.
• W2218454083 cites W2013415547 @default.
• W2218454083 cites W2013872799 @default.
• W2218454083 cites W2020038644 @default.
• W2218454083 cites W2021754558 @default.
• W2218454083 cites W2056785298 @default.
• W2218454083 cites W2058324844 @default.
• W2218454083 cites W2066979582 @default.
• W2218454083 cites W2079899752 @default.
• W2218454083 cites W2082197815 @default.
• W2218454083 cites W2085075824 @default.
• W2218454083 cites W2091982907 @default.
• W2218454083 cites W2097672374 @default.
• W2218454083 cites W2114597116 @default.
• W2218454083 cites W2114918553 @default.
• W2218454083 cites W2118672167 @default.
• W2218454083 cites W2124246220 @default.
• W2218454083 cites W2125331423 @default.
• W2218454083 cites W2135380002 @default.
• W2218454083 cites W2141830087 @default.
• W2218454083 cites W2414981839 @default.
• W2218454083 cites W371488 @default.
• W2218454083 cites W46056408 @default.
• W2218454083 doi "https://doi.org/10.1371/journal.pone.0128582" @default.
• W2218454083 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4452737" @default.
• W2218454083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26035307" @default.
• W2218454083 hasPublicationYear "2015" @default.
• W2218454083 type Work @default.
• W2218454083 sameAs 2218454083 @default.
• W2218454083 citedByCount "22" @default.
• W2218454083 countsByYear W22184540832015 @default.
• W2218454083 countsByYear W22184540832016 @default.
• W2218454083 countsByYear W22184540832017 @default.
• W2218454083 countsByYear W22184540832018 @default.
• W2218454083 countsByYear W22184540832019 @default.
• W2218454083 countsByYear W22184540832020 @default.
• W2218454083 countsByYear W22184540832021 @default.
• W2218454083 countsByYear W22184540832022 @default.
• W2218454083 countsByYear W22184540832023 @default.
• W2218454083 crossrefType "journal-article" @default.
• W2218454083 hasAuthorship W2218454083A5001229026 @default.
• W2218454083 hasAuthorship W2218454083A5008863193 @default.
• W2218454083 hasAuthorship W2218454083A5030702863 @default.
• W2218454083 hasAuthorship W2218454083A5033382787 @default.
• W2218454083 hasAuthorship W2218454083A5051779260 @default.
• W2218454083 hasAuthorship W2218454083A5052065929 @default.
• W2218454083 hasAuthorship W2218454083A5055158616 @default.
• W2218454083 hasAuthorship W2218454083A5080355318 @default.
• W2218454083 hasBestOaLocation W22184540831 @default.
• W2218454083 hasConcept C126322002 @default.
• W2218454083 hasConcept C134018914 @default.
• W2218454083 hasConcept C185592680 @default.
• W2218454083 hasConcept C2776779347 @default.
• W2218454083 hasConcept C2776970464 @default.
• W2218454083 hasConcept C2779651940 @default.
• W2218454083 hasConcept C55493867 @default.
• W2218454083 hasConcept C71924100 @default.
• W2218454083 hasConceptScore W2218454083C126322002 @default.
• W2218454083 hasConceptScore W2218454083C134018914 @default.
• W2218454083 hasConceptScore W2218454083C185592680 @default.
• W2218454083 hasConceptScore W2218454083C2776779347 @default.
• W2218454083 hasConceptScore W2218454083C2776970464 @default.
• W2218454083 hasConceptScore W2218454083C2779651940 @default.
• W2218454083 hasConceptScore W2218454083C55493867 @default.
• W2218454083 hasConceptScore W2218454083C71924100 @default.
• W2218454083 hasIssue "6" @default.
• W2218454083 hasLocation W22184540831 @default.
• W2218454083 hasLocation W22184540832 @default.
• W2218454083 hasLocation W22184540833 @default.
• W2218454083 hasLocation W22184540834 @default.
• W2218454083 hasLocation W22184540835 @default.
• W2218454083 hasOpenAccess W2218454083 @default.
• W2218454083 hasPrimaryLocation W22184540831 @default.

• next