Matches in SemOpenAlex for { <https://semopenalex.org/work/W2218537572> ?p ?o ?g. }
- W2218537572 abstract "Wolbachia is a wonderful anti-filarial target with many of its enzymes and surface proteins (WSPs) representing potential drug targets and vaccine candidates. Here we report on the immunologic response of a drug target, rsmD-like rRNA methyltransferase from Wolbachia endosymbiont of Brugia malayi. The recombinant protein generated both humoral and cell-mediated response in BALB/c mice but compromised its immunity. The humoral response was transient and endured barely for six months in mice with or without B. Malayi challenge. In splenocytes of mice, the key humoral immunity mediating cytokine IL4 was lowered (IL4↓) while IFNγ, the major cytokine mediating cellular immunity was decreased along with upregulation of IL10 cytokine (IFNγ↓, IL10↑). The finding here indicates that the enzyme has low immunogenicity and triggers lowering of cytokine level in BALB/c mice. Interestingly the overall immune profile can be summed up with equivalent response generated by WSP or whole Wolbachia." @default.
- W2218537572 created "2016-06-24" @default.
- W2218537572 creator A5026389624 @default.
- W2218537572 creator A5031357270 @default.
- W2218537572 creator A5055397205 @default.
- W2218537572 creator A5058366778 @default.
- W2218537572 date "2016-02-01" @default.
- W2218537572 modified "2023-09-22" @default.
- W2218537572 title "Immunological evaluation of an rsmD-like rRNA methyltransferase from Wolbachia endosymbiont of Brugia malayi" @default.
- W2218537572 cites W1536807865 @default.
- W2218537572 cites W1754166442 @default.
- W2218537572 cites W1983793312 @default.
- W2218537572 cites W1984296942 @default.
- W2218537572 cites W2000445038 @default.
- W2218537572 cites W2001693838 @default.
- W2218537572 cites W2006218982 @default.
- W2218537572 cites W2014655359 @default.
- W2218537572 cites W2018184373 @default.
- W2218537572 cites W2020438797 @default.
- W2218537572 cites W2022714365 @default.
- W2218537572 cites W2039643413 @default.
- W2218537572 cites W2065128144 @default.
- W2218537572 cites W2084458086 @default.
- W2218537572 cites W2085363526 @default.
- W2218537572 cites W2086760771 @default.
- W2218537572 cites W2090099105 @default.
- W2218537572 cites W2094845646 @default.
- W2218537572 cites W2116169815 @default.
- W2218537572 cites W2118116578 @default.
- W2218537572 cites W2120640222 @default.
- W2218537572 cites W2127477858 @default.
- W2218537572 cites W2148141602 @default.
- W2218537572 cites W2149984099 @default.
- W2218537572 cites W2151716155 @default.
- W2218537572 cites W2162602118 @default.
- W2218537572 cites W2286301987 @default.
- W2218537572 cites W4293247451 @default.
- W2218537572 cites W2166741983 @default.
- W2218537572 doi "https://doi.org/10.1016/j.cimid.2015.12.001" @default.
- W2218537572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26851594" @default.
- W2218537572 hasPublicationYear "2016" @default.
- W2218537572 type Work @default.
- W2218537572 sameAs 2218537572 @default.
- W2218537572 citedByCount "0" @default.
- W2218537572 crossrefType "journal-article" @default.
- W2218537572 hasAuthorship W2218537572A5026389624 @default.
- W2218537572 hasAuthorship W2218537572A5031357270 @default.
- W2218537572 hasAuthorship W2218537572A5055397205 @default.
- W2218537572 hasAuthorship W2218537572A5058366778 @default.
- W2218537572 hasConcept C104317684 @default.
- W2218537572 hasConcept C159047783 @default.
- W2218537572 hasConcept C165901193 @default.
- W2218537572 hasConcept C187316574 @default.
- W2218537572 hasConcept C191732599 @default.
- W2218537572 hasConcept C203014093 @default.
- W2218537572 hasConcept C2775848585 @default.
- W2218537572 hasConcept C2776548049 @default.
- W2218537572 hasConcept C2777629521 @default.
- W2218537572 hasConcept C2778690821 @default.
- W2218537572 hasConcept C2779341262 @default.
- W2218537572 hasConcept C2779356413 @default.
- W2218537572 hasConcept C2780868878 @default.
- W2218537572 hasConcept C3017875465 @default.
- W2218537572 hasConcept C54355233 @default.
- W2218537572 hasConcept C86803240 @default.
- W2218537572 hasConcept C8891405 @default.
- W2218537572 hasConceptScore W2218537572C104317684 @default.
- W2218537572 hasConceptScore W2218537572C159047783 @default.
- W2218537572 hasConceptScore W2218537572C165901193 @default.
- W2218537572 hasConceptScore W2218537572C187316574 @default.
- W2218537572 hasConceptScore W2218537572C191732599 @default.
- W2218537572 hasConceptScore W2218537572C203014093 @default.
- W2218537572 hasConceptScore W2218537572C2775848585 @default.
- W2218537572 hasConceptScore W2218537572C2776548049 @default.
- W2218537572 hasConceptScore W2218537572C2777629521 @default.
- W2218537572 hasConceptScore W2218537572C2778690821 @default.
- W2218537572 hasConceptScore W2218537572C2779341262 @default.
- W2218537572 hasConceptScore W2218537572C2779356413 @default.
- W2218537572 hasConceptScore W2218537572C2780868878 @default.
- W2218537572 hasConceptScore W2218537572C3017875465 @default.
- W2218537572 hasConceptScore W2218537572C54355233 @default.
- W2218537572 hasConceptScore W2218537572C86803240 @default.
- W2218537572 hasConceptScore W2218537572C8891405 @default.
- W2218537572 hasFunder F4320320721 @default.
- W2218537572 hasLocation W22185375721 @default.
- W2218537572 hasLocation W22185375722 @default.
- W2218537572 hasOpenAccess W2218537572 @default.
- W2218537572 hasPrimaryLocation W22185375721 @default.
- W2218537572 hasRelatedWork W1570963696 @default.
- W2218537572 hasRelatedWork W1964527676 @default.
- W2218537572 hasRelatedWork W1965519869 @default.
- W2218537572 hasRelatedWork W1995147387 @default.
- W2218537572 hasRelatedWork W2007952218 @default.
- W2218537572 hasRelatedWork W2009801114 @default.
- W2218537572 hasRelatedWork W2023061016 @default.
- W2218537572 hasRelatedWork W2065588157 @default.
- W2218537572 hasRelatedWork W2095668172 @default.
- W2218537572 hasRelatedWork W2109204017 @default.
- W2218537572 hasRelatedWork W2113681837 @default.
- W2218537572 hasRelatedWork W2127344664 @default.