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- W2218597924 abstract "Objectives: In the last decade gut microbialdiversity was associated with the pathogenesis of obesity in humans. Plasma citrulline was a simple and accurate biomarkerfor the severity of intestinal failure and was associated with short bowelsyndrome and alteration of gut permeability, being developed as an alternative to D-xylose tolerance test for the diagnosisof an abnormal small intestinal absorption of nutrients. This study wasperformed to ascertain whether obesity might be associated with dysregulationof epithelial gut function. Methods: Fifteen obese individuals (5 M/10 F; BMI37.4 ± 6.1 Kg/m2; 42 ± 6 yrs) and 15 healthy gender- and age-matchedcontrols (6 M/9 F BMI: 22.7 ± 2.1 Kg/m2; 39 ± 7 yrs) underwentD-xylose load (25 g) and plasma citrulline, plasma insulin, glucose and lipidprofile testing. Results: Plasma citrulline was significantly lower in theobese group (p = 0.045) with respectto controls, whilst total cholesterol, LDL and trygliceri- des concentration, insulin level and HOMA-IR weresignificantly higher in obese patients. In contrast, after D-xylose load no difference in serum xylosewas found between the two groups (p =ns). Conclusions: Obese patients showa decreased citrulline concentration with respect to lean subjects.Since citrulline is a known marker of intestinal health, alterations in the gutepithelium are likely to be associated withthe obesity syndrome. We propose to measure citrulline level in obese patients on a routine basis." @default.
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- W2218597924 date "2015-01-01" @default.
- W2218597924 modified "2023-10-16" @default.
- W2218597924 title "Plasma Citrulline: A New Marker of Gut Epithelium Alteration in Obese Patients?" @default.
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- W2218597924 doi "https://doi.org/10.4236/jdm.2015.54028" @default.
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