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- W221878519 abstract "In a previous study we reported an increased incidence of hypoploid metaphases in cultured lymphocytes of marihuana smokers. In these studies hypoploid metaphases were defined as metaphase nuclei with a chromosomal complement of less than 30 chromosomes. The purpose of the present study was to examine the cytogenetic effect of “ heavy ” marihuana smoking under a controlled environment. Five male subjects with prior histories of chronic marihuana smoking were used in this study. Subjects were initially kept in a drug-free environment. At the end of this period the subjects were encouraged to consume as many cigarettes as they could tolerate. The daily average was 14 cigarettes per day. Following the smoking period all subjects were deprived of marihuana for a period of over 18 days. Heparinized blood was obtained from all subjects before, during and after smoking. Metaphase and anaphase preparations were made from these samples. The incidence of hypoploid cells was significantly higher in all subjects during the smoking period. The incidence was also higher in samples obtained after the smoking period when compared with samples from before the smoking period. No increase in chromosome breakages or segregational errors of chromosomes in the anaphase preparations was found in any of the samples obtained. The increased incidence of hypoploid metaphases observed during heavy marihuana smoking in a controlled environment confirms our previous observation. These observations would suggest a causal relationship between moderate to heavy marihuana smoking and induction of hypoploid cells." @default.
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- W221878519 date "1979-01-01" @default.
- W221878519 modified "2023-09-26" @default.
- W221878519 title "HYPOPLOID METAPHASES IN CULTURED LYMPHOCYTES OF MARIHUANA SMOKERS" @default.
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- W221878519 doi "https://doi.org/10.1016/b978-0-08-023759-6.50032-9" @default.
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