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• W2219244418 startingPage "1" @default.
• W2219244418 abstract "When living organisms first evolved on the Earth, they did so under an atmosphere containing very little O2, i.e. they were essentially anaerobes. Anaerobic micro-organisms still survive to this day, but their growth is inhibited and they can often be killed by exposure to 21% O2, the current atmospheric level. As the O2 content of the atmosphere rose (as a result of the evolution of organisms with photosynthetic water-splitting capacity), many primitive organisms must have died. Present-day anaerobes are presumably the descendants of those primitive organisms that followed the evolutionary path of “adapting” to rising atmospheric O2 levels by restricting themselves to environments that the O2 did not penetrate. However, other organisms began the evolutionary process of evolving antioxidant defence systems to protect against O2 toxicity. In retrospect, this was a fruitful path to follow. Organisms that tolerated the presence of O2 could also evolve to use it for metabolic transformations (oxidases, oxygenases and synthases such as nitric oxide synthase [NOS]) and for efficient energy production by using electron transport chains with O2 as the terminal electron acceptor, such as those present in mitochondria. Human mitochondria make over 80% of the ATP that we need, and the lethal effects of inhibiting this, e.g. by cyanide, show how important the mitochondria are. Mitochondrial defects contribute to the pathology of a wide range of diseases, as shown in subsequent chapters of this book.KeywordsXanthine OxidaseReactive Nitrogen SpeciesPeroxyl RadicalHypochlorous AcidPeroxynitrous AcidThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
• W2219244418 created "2016-06-24" @default.
• W2219244418 creator A5053726981 @default.
• W2219244418 date "1998-01-01" @default.
• W2219244418 modified "2023-09-23" @default.
• W2219244418 title "Free radicals and oxidative damage in biology and medicine: An introduction" @default.
• W2219244418 cites W1272300955 @default.
• W2219244418 cites W1489860413 @default.
• W2219244418 cites W1502445277 @default.
• W2219244418 cites W1502941123 @default.
• W2219244418 cites W1535816350 @default.
• W2219244418 cites W1560777399 @default.
• W2219244418 cites W1575826813 @default.
• W2219244418 cites W1600359323 @default.
• W2219244418 cites W1604789505 @default.
• W2219244418 cites W1676512302 @default.
• W2219244418 cites W1734082729 @default.
• W2219244418 cites W1759706356 @default.
• W2219244418 cites W1782873284 @default.
• W2219244418 cites W1952402412 @default.
• W2219244418 cites W1964726234 @default.
• W2219244418 cites W1964874569 @default.
• W2219244418 cites W1968499584 @default.
• W2219244418 cites W1969023744 @default.
• W2219244418 cites W1972802911 @default.
• W2219244418 cites W1974185399 @default.
• W2219244418 cites W1975299003 @default.
• W2219244418 cites W1975515113 @default.
• W2219244418 cites W1976911231 @default.
• W2219244418 cites W1980834707 @default.
• W2219244418 cites W1981912201 @default.
• W2219244418 cites W1983400389 @default.
• W2219244418 cites W1989812133 @default.
• W2219244418 cites W1994669073 @default.
• W2219244418 cites W1997745709 @default.
• W2219244418 cites W1998228104 @default.
• W2219244418 cites W2003711294 @default.
• W2219244418 cites W2005921112 @default.
• W2219244418 cites W2006625643 @default.
• W2219244418 cites W2006946054 @default.
• W2219244418 cites W201008269 @default.
• W2219244418 cites W2010257889 @default.
• W2219244418 cites W2013376841 @default.
• W2219244418 cites W2014496233 @default.
• W2219244418 cites W2015380696 @default.
• W2219244418 cites W2023677185 @default.
• W2219244418 cites W2025824008 @default.
• W2219244418 cites W2028929319 @default.
• W2219244418 cites W2032092394 @default.
• W2219244418 cites W2033381823 @default.
• W2219244418 cites W2033624890 @default.
• W2219244418 cites W2036682827 @default.
• W2219244418 cites W2037001735 @default.
• W2219244418 cites W2037577591 @default.
• W2219244418 cites W2038443620 @default.
• W2219244418 cites W2051802937 @default.
• W2219244418 cites W2051899684 @default.
• W2219244418 cites W2058821788 @default.
• W2219244418 cites W2061142443 @default.
• W2219244418 cites W2061885883 @default.
• W2219244418 cites W2063021917 @default.
• W2219244418 cites W2063552957 @default.
• W2219244418 cites W2065661936 @default.
• W2219244418 cites W2072978915 @default.
• W2219244418 cites W2076429988 @default.
• W2219244418 cites W2079398419 @default.
• W2219244418 cites W2080207006 @default.
• W2219244418 cites W2087141403 @default.
• W2219244418 cites W2087426267 @default.
• W2219244418 cites W2094655287 @default.
• W2219244418 cites W2096942880 @default.
• W2219244418 cites W2098947204 @default.
• W2219244418 cites W2099530293 @default.
• W2219244418 cites W2102723961 @default.
• W2219244418 cites W2109893157 @default.
• W2219244418 cites W2111292506 @default.
• W2219244418 cites W2132416882 @default.
• W2219244418 cites W2132826785 @default.
• W2219244418 cites W2133451731 @default.
• W2219244418 cites W2137434543 @default.
• W2219244418 cites W2138188400 @default.
• W2219244418 cites W2139106784 @default.
• W2219244418 cites W2142115579 @default.
• W2219244418 cites W2149922717 @default.
• W2219244418 cites W2149959669 @default.
• W2219244418 cites W2152719751 @default.
• W2219244418 cites W2161446029 @default.
• W2219244418 cites W2164613158 @default.
• W2219244418 cites W2167762171 @default.
• W2219244418 cites W2170036297 @default.
• W2219244418 cites W2171615170 @default.
• W2219244418 cites W2202554561 @default.
• W2219244418 cites W2204123985 @default.
• W2219244418 cites W2277880905 @default.
• W2219244418 cites W2280410994 @default.
• W2219244418 cites W2290967234 @default.
• W2219244418 cites W2313326603 @default.
• W2219244418 cites W2326202471 @default.

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