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- W2219373288 abstract "FK 506 is a macrolide isolated from the cultures of the fungus Streptomyces tsukubaensis.1 It is nearly 200 times more potent than cyclosporine (CyA) in inhibiting lymphocyte proliferation in mixed lymphocyte cultures.2 FK 506 has been shown to prevent or reverse the rejection of heart, liver, kidney, pancreas, lung, intestine, and skin grafts in mice, rats, dogs, monkeys, and baboons.3,4 FK 506 is currently undergoing clinical trials at the University of Pittsburgh. Preliminary results indicate that FK 506 provides better immunosuppression in liver transplant recipients than CyA.5Previous in vitro and in vivo studies have shown synergism of immunosuppressive activity between FK 506 and CyA.2,6 Coadministration of FK 506 with CyA has also been shown to result in increased nephrotoxicity in animals and humans. 7,8 The mechanism of such an interaction is currently not understood. Such interaction may be mediated through an influence of FK 506 on the absorption, distribution, or elimination of CyA. The objective of the present study was to characterize the mechanism responsible for the observed interaction between CyA and FK 506 in an animal model." @default.
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- W2219373288 date "1991-12-01" @default.
- W2219373288 modified "2023-09-23" @default.
- W2219373288 title "Interaction between FK 506 and cyclosporine in dogs." @default.
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