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• W2219682016 abstract "a b s t r a c t We describe a rapid method to accurately measure the cytotoxicity of mammalian cells upon expo- sure to various drugs. Using this assay, we obtain survival data in a fraction of the time required to perform the traditional clonogenic survival assay, considered the gold standard. The dynamic range of the assay allows sensitivity measurements on a multi-log scale allowing better resolution of compara- tive sensitivities. Moreover, the results obtained contain additional information on cell cycle effects of the drug treatment. Cell survival is obtained from a quantitative comparison of proliferation between drug-treated and untreated cells. During the assay, cells are treated with a drug and, following a recov- ery period, allowed to proliferate in the presence of bromodeoxyuridine (BrdU). Cells that synthesize DNA in the presence of BrdU exhibit quenched Hoechst fluorescence, easily detected by flow cytometry; quenching is used to determine relative proliferation in treated vs. untreated cells. Finally, this assay can be used in high-throughput format to simultaneously screen multiple cell lines and drugs for accurate measurements of cell survival and cell cycle effects after drug treatment." @default.
• W2219682016 created "2016-06-24" @default.
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• W2219682016 creator A5047514569 @default.
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• W2219682016 date "2011-11-01" @default.
• W2219682016 modified "2023-09-28" @default.
• W2219682016 title "A rapid survival assay to measure drug-induced cytotoxicity and cell cycle effects" @default.
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