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- W2219815071 abstract "RNA interference (RNAi) is an evolutionarily conserved gene-silencing phenomenon that shows great promise for developing new therapies. However, the development of small interfering RNA (siRNA)-based therapies need to establish efficient delivery system that silences target genes with siRNA doses that is clinically feasible in humans. Here we report synthesis and in vivo study of a novel PEGylated curdlan-based nanoparticle, designated as 6AC-100PEG, obtained by conjugation of mPEG 2000 to 6-amino-6-deoxy-curdlan. The complex of siRNA/6AC-100PEG showed homogenous nanoparticles with an average diameter of 200 nm. MTT assay indicated that 6AC-100PEG does not have apparent cytotoxicity. Systemic administration of a complex of siapoB/6AC-100PEG significantly reduced the level of apoB mRNA in mouse liver, indicating that 6AC-100PEG can efficiently deliver siRNA to mouse liver and induce RNAi. Administration of siRNA/6AC-100PEG to mouse did not elevate liver enzyme level in the serum, indicating that 6AC-100PEG nanoparticle is a promising in vivo siRNA delivery agent." @default.
- W2219815071 created "2016-06-24" @default.
- W2219815071 creator A5003413953 @default.
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- W2219815071 date "2016-05-01" @default.
- W2219815071 modified "2023-10-09" @default.
- W2219815071 title "PEGylation of 6-amino-6-deoxy-curdlan for efficient in vivo siRNA delivery" @default.
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- W2219815071 doi "https://doi.org/10.1016/j.carbpol.2015.12.077" @default.
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