FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2219821844> ?p ?o ?g. }

• W2219821844 endingPage "113" @default.
• W2219821844 startingPage "102" @default.
• W2219821844 abstract "Small peptides formed from non-ribosomal peptide synthetases (NRPS) are bioactive molecules produced by many fungi including the genus Aspergillus. A subset of NRPS utilizes tryptophan and its precursor, the non-proteinogenic amino acid anthranilate, in synthesis of various metabolites such as Aspergillus fumigatus fumiquinazolines (Fqs) produced by the fmq gene cluster. The A. fumigatus genome contains two putative anthranilate synthases - a key enzyme in conversion of anthranilic acid to tryptophan - one beside the fmq cluster and one in a region of co-linearity with other Aspergillus spp. Only the gene found in the co-linear region, trpE, was involved in tryptophan biosynthesis. We found that site-specific mutations of the TrpE feedback domain resulted in significantly increased production of anthranilate, tryptophan, p-aminobenzoate and fumiquinazolines FqF and FqC. Supplementation with tryptophan restored metabolism to near wild type levels in the feedback mutants and suggested that synthesis of the tryptophan degradation product kynurenine could negatively impact Fq synthesis. The second putative anthranilate synthase gene next to the fmq cluster was termed icsA for its considerable identity to isochorismate synthases in bacteria. Although icsA had no impact on A. fumigatus Fq production, deletion and over-expression of icsA increased and decreased respectively aromatic amino acid levels suggesting that IcsA can draw from the cellular chorismate pool." @default.
• W2219821844 created "2016-06-24" @default.
• W2219821844 creator A5011009871 @default.
• W2219821844 creator A5033525768 @default.
• W2219821844 creator A5033856495 @default.
• W2219821844 creator A5063602018 @default.
• W2219821844 creator A5089340042 @default.
• W2219821844 creator A5089831622 @default.
• W2219821844 date "2016-04-01" @default.
• W2219821844 modified "2023-10-03" @default.
• W2219821844 title "TrpE feedback mutants reveal roadblocks and conduits toward increasing secondary metabolism in Aspergillus fumigatus" @default.
• W2219821844 cites W1588343339 @default.
• W2219821844 cites W1600809398 @default.
• W2219821844 cites W1789727791 @default.
• W2219821844 cites W1844343897 @default.
• W2219821844 cites W1900002559 @default.
• W2219821844 cites W1909891465 @default.
• W2219821844 cites W1970309616 @default.
• W2219821844 cites W1974227348 @default.
• W2219821844 cites W1977014309 @default.
• W2219821844 cites W1984725847 @default.
• W2219821844 cites W1985937527 @default.
• W2219821844 cites W1987006794 @default.
• W2219821844 cites W1993657844 @default.
• W2219821844 cites W1999923196 @default.
• W2219821844 cites W2001818248 @default.
• W2219821844 cites W2020669856 @default.
• W2219821844 cites W2026308334 @default.
• W2219821844 cites W2029979826 @default.
• W2219821844 cites W2032771274 @default.
• W2219821844 cites W2044091494 @default.
• W2219821844 cites W2049709457 @default.
• W2219821844 cites W2049940795 @default.
• W2219821844 cites W2053733024 @default.
• W2219821844 cites W2054217409 @default.
• W2219821844 cites W2057227690 @default.
• W2219821844 cites W2060081344 @default.
• W2219821844 cites W2062946300 @default.
• W2219821844 cites W2063464385 @default.
• W2219821844 cites W2064376071 @default.
• W2219821844 cites W2065658076 @default.
• W2219821844 cites W2068477017 @default.
• W2219821844 cites W2073518671 @default.
• W2219821844 cites W2077076461 @default.
• W2219821844 cites W2077600598 @default.
• W2219821844 cites W2084817288 @default.
• W2219821844 cites W2087753924 @default.
• W2219821844 cites W2091471193 @default.
• W2219821844 cites W2092125897 @default.
• W2219821844 cites W2094665321 @default.
• W2219821844 cites W2095597362 @default.
• W2219821844 cites W2103614656 @default.
• W2219821844 cites W2105329815 @default.
• W2219821844 cites W2106932184 @default.
• W2219821844 cites W2110856516 @default.
• W2219821844 cites W2116008187 @default.
• W2219821844 cites W2116798591 @default.
• W2219821844 cites W2126158040 @default.
• W2219821844 cites W2127543426 @default.
• W2219821844 cites W2127774996 @default.
• W2219821844 cites W2129994851 @default.
• W2219821844 cites W2134594856 @default.
• W2219821844 cites W2136266267 @default.
• W2219821844 cites W2143989967 @default.
• W2219821844 cites W2144881642 @default.
• W2219821844 cites W2157594951 @default.
• W2219821844 cites W2160808433 @default.
• W2219821844 cites W2161742145 @default.
• W2219821844 cites W2166445455 @default.
• W2219821844 cites W2169859890 @default.
• W2219821844 cites W2332831701 @default.
• W2219821844 cites W4237570409 @default.
• W2219821844 doi "https://doi.org/10.1016/j.fgb.2015.12.002" @default.
• W2219821844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4789178" @default.
• W2219821844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26701311" @default.
• W2219821844 hasPublicationYear "2016" @default.
• W2219821844 type Work @default.
• W2219821844 sameAs 2219821844 @default.
• W2219821844 citedByCount "23" @default.
• W2219821844 countsByYear W22198218442016 @default.
• W2219821844 countsByYear W22198218442017 @default.
• W2219821844 countsByYear W22198218442018 @default.
• W2219821844 countsByYear W22198218442019 @default.
• W2219821844 countsByYear W22198218442020 @default.
• W2219821844 countsByYear W22198218442021 @default.
• W2219821844 countsByYear W22198218442022 @default.
• W2219821844 countsByYear W22198218442023 @default.
• W2219821844 crossrefType "journal-article" @default.
• W2219821844 hasAuthorship W2219821844A5011009871 @default.
• W2219821844 hasAuthorship W2219821844A5033525768 @default.
• W2219821844 hasAuthorship W2219821844A5033856495 @default.
• W2219821844 hasAuthorship W2219821844A5063602018 @default.
• W2219821844 hasAuthorship W2219821844A5089340042 @default.
• W2219821844 hasAuthorship W2219821844A5089831622 @default.
• W2219821844 hasBestOaLocation W22198218442 @default.
• W2219821844 hasConcept C104317684 @default.
• W2219821844 hasConcept C143065580 @default.
• W2219821844 hasConcept C2776706248 @default.

• next