FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2220083485> ?p ?o ?g. }

• W2220083485 endingPage "51" @default.
• W2220083485 startingPage "44" @default.
• W2220083485 abstract "Vascular diseases such as atherosclerosis and restenosis artery angioplasty are associated with vascular smooth muscle cell (VSMC) proliferation and intimal thickening arterial walls. In the present study, we investigated the inhibitory effects of sulforaphane, an isothiocyanate produced in cruciferous vegetables, on VSMC proliferation and neointimal formation in a rat carotid artery injury model. Sulforaphane at the concentrations of 0.5, 1.0, and 2.0 μM significantly inhibited platelet-derived growth factor (PDGF)-BB-induced VSMC proliferation in a concentration-dependent manner, determined by cell count. The IC50 value of sulforaphane-inhibited VSMC proliferation was 0.8 μM. Sulforaphane increased the cyclin-dependent kinase inhibitor p21 and p53 levels, while it decreased CDK2 and cyclin E expression. The effects of sulforaphane on vascular thickening were determined 14 days after the injury to the rat carotid artery. The angiographic mean luminary diameters of the group treated with 2 and 4 μM sulforaphane were 0.25±0.1 and 0.09±0.1 mm², respectively, while the value of the control groups was 0.40±0.1 mm², indicating that sulforaphane may inhibit neointimal formation. The expression of PCNA, maker for cell cycle arrest, was decreased, while that of p53 and p21 was increased, which showed the same pattern as one in in-vitro study. These results suggest that sulforaphane-inhibited VSMC proliferation may occur through the G1/S cell cycle arrest by up-regulation of p53 signaling pathway, and then lead to the decreased neointimal hyperplasia thickening. Thus, sulforaphane may be a promising candidate for the therapy of atherosclerosis and post-angiography restenosis." @default.
• W2220083485 created "2016-06-24" @default.
• W2220083485 creator A5024429113 @default.
• W2220083485 creator A5029584856 @default.
• W2220083485 creator A5033890698 @default.
• W2220083485 creator A5037191860 @default.
• W2220083485 creator A5042408712 @default.
• W2220083485 creator A5045871251 @default.
• W2220083485 creator A5056876096 @default.
• W2220083485 creator A5091185492 @default.
• W2220083485 date "2013-07-01" @default.
• W2220083485 modified "2023-10-01" @default.
• W2220083485 title "Sulforaphane inhibits PDGF-induced proliferation of rat aortic vascular smooth muscle cell by up-regulation of p53 leading to G1/S cell cycle arrest" @default.
• W2220083485 cites W1522198934 @default.
• W2220083485 cites W1972305847 @default.
• W2220083485 cites W1972995842 @default.
• W2220083485 cites W1975827192 @default.
• W2220083485 cites W1981546327 @default.
• W2220083485 cites W1985264467 @default.
• W2220083485 cites W1987430295 @default.
• W2220083485 cites W1990374879 @default.
• W2220083485 cites W1993487598 @default.
• W2220083485 cites W2011234976 @default.
• W2220083485 cites W2012356144 @default.
• W2220083485 cites W2014687097 @default.
• W2220083485 cites W2025670033 @default.
• W2220083485 cites W2038173255 @default.
• W2220083485 cites W2070061120 @default.
• W2220083485 cites W2080155284 @default.
• W2220083485 cites W2090834124 @default.
• W2220083485 cites W2097269034 @default.
• W2220083485 cites W2102791751 @default.
• W2220083485 cites W2121619780 @default.
• W2220083485 cites W2125792588 @default.
• W2220083485 cites W2131480172 @default.
• W2220083485 cites W2137570167 @default.
• W2220083485 cites W2138392378 @default.
• W2220083485 cites W2147631083 @default.
• W2220083485 cites W2151592540 @default.
• W2220083485 cites W2151890309 @default.
• W2220083485 cites W2162703942 @default.
• W2220083485 doi "https://doi.org/10.1016/j.vph.2013.06.003" @default.
• W2220083485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23810908" @default.
• W2220083485 hasPublicationYear "2013" @default.
• W2220083485 type Work @default.
• W2220083485 sameAs 2220083485 @default.
• W2220083485 citedByCount "33" @default.
• W2220083485 countsByYear W22200834852014 @default.
• W2220083485 countsByYear W22200834852015 @default.
• W2220083485 countsByYear W22200834852016 @default.
• W2220083485 countsByYear W22200834852017 @default.
• W2220083485 countsByYear W22200834852018 @default.
• W2220083485 countsByYear W22200834852019 @default.
• W2220083485 countsByYear W22200834852021 @default.
• W2220083485 countsByYear W22200834852022 @default.
• W2220083485 countsByYear W22200834852023 @default.
• W2220083485 crossrefType "journal-article" @default.
• W2220083485 hasAuthorship W2220083485A5024429113 @default.
• W2220083485 hasAuthorship W2220083485A5029584856 @default.
• W2220083485 hasAuthorship W2220083485A5033890698 @default.
• W2220083485 hasAuthorship W2220083485A5037191860 @default.
• W2220083485 hasAuthorship W2220083485A5042408712 @default.
• W2220083485 hasAuthorship W2220083485A5045871251 @default.
• W2220083485 hasAuthorship W2220083485A5056876096 @default.
• W2220083485 hasAuthorship W2220083485A5091185492 @default.
• W2220083485 hasConcept C105696609 @default.
• W2220083485 hasConcept C134018914 @default.
• W2220083485 hasConcept C1491633281 @default.
• W2220083485 hasConcept C170493617 @default.
• W2220083485 hasConcept C180361614 @default.
• W2220083485 hasConcept C185592680 @default.
• W2220083485 hasConcept C2775960820 @default.
• W2220083485 hasConcept C2779395532 @default.
• W2220083485 hasConcept C2780841255 @default.
• W2220083485 hasConcept C29537977 @default.
• W2220083485 hasConcept C2992686903 @default.
• W2220083485 hasConcept C55493867 @default.
• W2220083485 hasConcept C62112901 @default.
• W2220083485 hasConcept C86803240 @default.
• W2220083485 hasConcept C95444343 @default.
• W2220083485 hasConceptScore W2220083485C105696609 @default.
• W2220083485 hasConceptScore W2220083485C134018914 @default.
• W2220083485 hasConceptScore W2220083485C1491633281 @default.
• W2220083485 hasConceptScore W2220083485C170493617 @default.
• W2220083485 hasConceptScore W2220083485C180361614 @default.
• W2220083485 hasConceptScore W2220083485C185592680 @default.
• W2220083485 hasConceptScore W2220083485C2775960820 @default.
• W2220083485 hasConceptScore W2220083485C2779395532 @default.
• W2220083485 hasConceptScore W2220083485C2780841255 @default.
• W2220083485 hasConceptScore W2220083485C29537977 @default.
• W2220083485 hasConceptScore W2220083485C2992686903 @default.
• W2220083485 hasConceptScore W2220083485C55493867 @default.
• W2220083485 hasConceptScore W2220083485C62112901 @default.
• W2220083485 hasConceptScore W2220083485C86803240 @default.
• W2220083485 hasConceptScore W2220083485C95444343 @default.
• W2220083485 hasFunder F4320322120 @default.
• W2220083485 hasIssue "1-2" @default.
• W2220083485 hasLocation W22200834851 @default.

• next