Matches in SemOpenAlex for { <https://semopenalex.org/work/W2220115260> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2220115260 endingPage "74" @default.
- W2220115260 startingPage "68" @default.
- W2220115260 abstract "Vitis amurensis (VA; Vitaceae) has long been used in oriental herbal medicine. It has been reported that roots and seeds of VA have anti-inflammatory and antioxidant effects. In the present study, the protective effect of ethanol extract from stems and leaves of VA on hydrogen peroxide (H2O2) (100 μm)-induced neuronal cell damage was examined in primary cultured rat cortical neurons. VA (10-100 μg/ml) concentration-dependently inhibited H2O2-induced apoptotic neuronal cell death measured by 3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) assay and Hoechst 33342 staining. VA inhibited H2O2-induced elevation of intracellular Ca2+ concentration ([Ca2+]i) and generation of reactive oxygen species (ROS), which were measured by fluorescent dyes. Pretreatment of VA also prevented glutamate release into medium induced by 100 μm H2O2, which was measured by HPLC. These results suggest that VA showed a neuroprotective effect on H2O2-induced neuronal cell death by interfering with H2O2-induced elevation of [Ca2+]i, glutamate release, and ROS generation. This has a significant meaning of finding a new pharmacological activity of stems and leaves of VA in the CNS." @default.
- W2220115260 created "2016-06-24" @default.
- W2220115260 creator A5021868489 @default.
- W2220115260 creator A5035271244 @default.
- W2220115260 creator A5044606215 @default.
- W2220115260 creator A5046214704 @default.
- W2220115260 creator A5061294938 @default.
- W2220115260 creator A5075016994 @default.
- W2220115260 date "2009-02-28" @default.
- W2220115260 modified "2023-09-24" @default.
- W2220115260 title "과산화수소수로 유도된 배양 뇌신경세포손상에 대한 왕머루 잎과 줄기 추출물의 보호효과" @default.
- W2220115260 hasPublicationYear "2009" @default.
- W2220115260 type Work @default.
- W2220115260 sameAs 2220115260 @default.
- W2220115260 citedByCount "0" @default.
- W2220115260 crossrefType "journal-article" @default.
- W2220115260 hasAuthorship W2220115260A5021868489 @default.
- W2220115260 hasAuthorship W2220115260A5035271244 @default.
- W2220115260 hasAuthorship W2220115260A5044606215 @default.
- W2220115260 hasAuthorship W2220115260A5046214704 @default.
- W2220115260 hasAuthorship W2220115260A5061294938 @default.
- W2220115260 hasAuthorship W2220115260A5075016994 @default.
- W2220115260 hasConcept C153911025 @default.
- W2220115260 hasConcept C170493617 @default.
- W2220115260 hasConcept C185592680 @default.
- W2220115260 hasConcept C190283241 @default.
- W2220115260 hasConcept C25498285 @default.
- W2220115260 hasConcept C2778004101 @default.
- W2220115260 hasConcept C2780369685 @default.
- W2220115260 hasConcept C31573885 @default.
- W2220115260 hasConcept C48349386 @default.
- W2220115260 hasConcept C533411734 @default.
- W2220115260 hasConcept C55493867 @default.
- W2220115260 hasConcept C61174792 @default.
- W2220115260 hasConcept C79879829 @default.
- W2220115260 hasConcept C86803240 @default.
- W2220115260 hasConcept C98274493 @default.
- W2220115260 hasConceptScore W2220115260C153911025 @default.
- W2220115260 hasConceptScore W2220115260C170493617 @default.
- W2220115260 hasConceptScore W2220115260C185592680 @default.
- W2220115260 hasConceptScore W2220115260C190283241 @default.
- W2220115260 hasConceptScore W2220115260C25498285 @default.
- W2220115260 hasConceptScore W2220115260C2778004101 @default.
- W2220115260 hasConceptScore W2220115260C2780369685 @default.
- W2220115260 hasConceptScore W2220115260C31573885 @default.
- W2220115260 hasConceptScore W2220115260C48349386 @default.
- W2220115260 hasConceptScore W2220115260C533411734 @default.
- W2220115260 hasConceptScore W2220115260C55493867 @default.
- W2220115260 hasConceptScore W2220115260C61174792 @default.
- W2220115260 hasConceptScore W2220115260C79879829 @default.
- W2220115260 hasConceptScore W2220115260C86803240 @default.
- W2220115260 hasConceptScore W2220115260C98274493 @default.
- W2220115260 hasIssue "1" @default.
- W2220115260 hasLocation W22201152601 @default.
- W2220115260 hasOpenAccess W2220115260 @default.
- W2220115260 hasPrimaryLocation W22201152601 @default.
- W2220115260 hasVolume "17" @default.
- W2220115260 isParatext "false" @default.
- W2220115260 isRetracted "false" @default.
- W2220115260 magId "2220115260" @default.
- W2220115260 workType "article" @default.