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• W2220153722 abstract "Actin filaments in plant cells are incredibly dynamic; they undergo incessant remodeling and assembly or disassembly within seconds. These dynamic events are choreographed by a plethora of actin-binding proteins, but the exact mechanisms are poorly understood. Here, we dissect the contribution of Arabidopsis (Arabidopsis thaliana) PROFILIN1 (PRF1), a conserved actin monomer-binding protein, to actin organization and single filament dynamics during axial cell expansion of living epidermal cells. We found that reduced PRF1 levels enhanced cell and organ growth. Surprisingly, we observed that the overall frequency of nucleation events in prf1 mutants was dramatically decreased and that a subpopulation of actin filaments that assemble at high rates was reduced. To test whether profilin cooperates with plant formin proteins to execute actin nucleation and rapid filament elongation in cells, we used a pharmacological approach. Here, we used Small Molecule Inhibitor of Formin FH2 (SMIFH2), after validating its mode of action on a plant formin in vitro, and observed a reduced nucleation frequency of actin filaments in live cells. Treatment of wild-type epidermal cells with SMIFH2 mimicked the phenotype of prf1 mutants, and the nucleation frequency in prf1-2 mutant was completely insensitive to these treatments. Our data provide compelling evidence that PRF1 coordinates the stochastic dynamic properties of actin filaments by modulating formin-mediated actin nucleation and assembly during plant cell expansion." @default.
• W2220153722 created "2016-06-24" @default.
• W2220153722 creator A5022594818 @default.
• W2220153722 creator A5055152033 @default.
• W2220153722 creator A5061615379 @default.
• W2220153722 creator A5074302707 @default.
• W2220153722 date "2015-11-16" @default.
• W2220153722 modified "2023-09-27" @default.
• W2220153722 title "Profilin-Dependent Nucleation and Assembly of Actin Filaments Controls Cell Elongation in Arabidopsis" @default.
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• W2220153722 cites W1879332326 @default.
• W2220153722 cites W1965146987 @default.
• W2220153722 cites W1968520335 @default.
• W2220153722 cites W1970195231 @default.
• W2220153722 cites W1975953734 @default.
• W2220153722 cites W1984332521 @default.
• W2220153722 cites W1986279985 @default.
• W2220153722 cites W1986416324 @default.
• W2220153722 cites W1986576270 @default.
• W2220153722 cites W1988635195 @default.
• W2220153722 cites W1992440587 @default.
• W2220153722 cites W1996675613 @default.
• W2220153722 cites W2000913872 @default.
• W2220153722 cites W2011017251 @default.
• W2220153722 cites W2015063578 @default.
• W2220153722 cites W2019125570 @default.
• W2220153722 cites W2027685333 @default.
• W2220153722 cites W2028189102 @default.
• W2220153722 cites W2032152816 @default.
• W2220153722 cites W2033171775 @default.
• W2220153722 cites W2033575518 @default.
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• W2220153722 cites W2045590135 @default.
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• W2220153722 cites W2066276302 @default.
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• W2220153722 cites W2070119451 @default.
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• W2220153722 cites W2081875880 @default.
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• W2220153722 doi "https://doi.org/10.1104/pp.15.01321" @default.
• W2220153722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4704583" @default.
• W2220153722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26574597" @default.
• W2220153722 hasPublicationYear "2015" @default.
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