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- W2220222167 abstract "Aging is associated with reductions in hippocampal volume that are accelerated by Alzheimer's disease and vascular risk factors. Our genome-wide association study (GWAS) of dementia-free persons ( n = 9,232) identified 46 SNPs at four loci with P values of −7 . In two additional samples ( n = 2,318), associations were replicated at 12q14 within MSRB3 - WIF1 (discovery and replication; rs17178006; P = 5.3 × 10 −11 ) and at 12q24 near HRK - FBXW8 (rs7294919; P = 2.9 × 10 −11 ). Remaining associations included one SNP at 2q24 within DPP4 (rs6741949; P = 2.9 × 10 −7 ) and nine SNPs at 9p33 within ASTN2 (rs7852872; P = 1.0 × 10 −7 ); along with the chromosome 12 associations, these loci were also associated with hippocampal volume ( P n = 7,794). The SNP in ASTN2 also showed suggestive association with decline in cognition in a largely independent sample ( n = 1,563). These associations implicate genes related to apoptosis ( HRK ), development ( WIF1) , oxidative stress ( MSR3B ), ubiquitination ( FBXW8 ) and neuronal migration ( ASTN2 ), as well as enzymes targeted by new diabetes medications ( DPP4 ), indicating new genetic influences on hippocampal size and possibly the risk of cognitive decline and dementia." @default.
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- W2220222167 date "2012-04-15" @default.
- W2220222167 modified "2023-10-18" @default.
- W2220222167 title "Common variants at 12q14 and 12q24 are associated with hippocampal volume" @default.
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