FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W222030266> ?p ?o ?g. }

• W222030266 abstract "Background: Thrombin and platelets are directly involved in arterial thrombosis, typically occurring at sites of atherosclerotic plaque rupture among patients with acute coronary syndromes. Understanding the dynamic nature of pathologic thrombosis has important clinical implications. Methods: Fibrinopeptide A (FPA), thrombin-antithrombin complexes (TAT), and prothrombin activation fragment 1.2 (F1.2), plasma markers of fibrin formation (thrombin activ- ity) and thrombin generation, and platelet activation, deter- mined by the recognition of a surface-expressed platelet a-granule protein, P-seleetin, using flow eytometry, were measured in 36 consecutive patients with unstable angina and non-Q-wave myocardial infarction participating in the Thrombolysis In Myocardial Ischemia (TIMI) III B trial. Results: Thrombin generation (TAT 12.1 -+ 17.8 ng/ml vs. 3.4 -+ 1.0 ng/ml; F1.2 0.19 - 0.14 nmol/l vs. 0.12 - 0.8 nmol/l), fibrin formation (FPA 15.8 - 23.5 ng/ml vs. 7.5 -+ 2.3 ng/ ml), and platelet activation) 10.6 - 2.4% vs. 2.5 -+ 2.0%) were increased significantly in patients compared with healthy, age-matched controls (p < 0.01). Fibrin formation, repre- sented by plasma FPA levels, did not correlate with the per- centage of activated platelets (r = -.10, p = 0.69). Thrombin generation and platelet activation also did not correlate. A statistically insignificant trend between TAT and platelet ac- tivation was observed (r = .42, p = 0.07); however, even with TAT levels in excess of 20 ng/ml (nearly sixfold greater than normal healthy controls) platelet activation was increased by only 1.7-fold. Conclusions: Thrombin generation, fibrin formation, and platelet activation are increased modestly among patients with unstable angina and non-Q-wave myo- cardial infarction. Despite the involvement of platelets and coagulation proteins in arterial thrombotic processes, their relative contributions may vary, providing a pathophysio- logic basis for the dynamic expression of disease and response to treatment observed commonly in clinical practice. Rupture or fissuring of intimal plaques is known to occur frequently in the evolution of human atheroscle- rotic coronary artery disease. Plaque ruptures vary considerably in size and depth. While most are micro- scopic, others are extensive; both occur at the plaques periphery, where the fibrous cap is thinnest and most heavily infiltrated by foam cells (lipid-laden macro-" @default.
• W222030266 created "2016-06-24" @default.
• W222030266 creator A5004956623 @default.
• W222030266 creator A5048908501 @default.
• W222030266 creator A5068343035 @default.
• W222030266 creator A5075389112 @default.
• W222030266 creator A5083909396 @default.
• W222030266 creator A5089213415 @default.
• W222030266 creator A5089591844 @default.
• W222030266 date "1995-01-01" @default.
• W222030266 modified "2023-09-27" @default.
• W222030266 title "Dynamic Nature of Thrombin Generation, Formation, and Platelet Activation in Unstable Angina and Non-Q-Wave Myocardial Infarction Fibrin" @default.
• W222030266 cites W1495037852 @default.
• W222030266 cites W1593965037 @default.
• W222030266 cites W19132231 @default.
• W222030266 cites W2008293739 @default.
• W222030266 cites W2012105739 @default.
• W222030266 cites W2014279568 @default.
• W222030266 cites W2018891963 @default.
• W222030266 cites W2028061814 @default.
• W222030266 cites W2030756815 @default.
• W222030266 cites W2032253971 @default.
• W222030266 cites W2035542600 @default.
• W222030266 cites W2037476845 @default.
• W222030266 cites W2047172923 @default.
• W222030266 cites W2049364649 @default.
• W222030266 cites W2079184391 @default.
• W222030266 cites W2082501322 @default.
• W222030266 cites W2087098935 @default.
• W222030266 cites W2088634464 @default.
• W222030266 cites W2089406251 @default.
• W222030266 cites W2093996647 @default.
• W222030266 cites W2110852564 @default.
• W222030266 cites W2118941984 @default.
• W222030266 cites W2152575341 @default.
• W222030266 cites W2166927171 @default.
• W222030266 cites W2319834083 @default.
• W222030266 cites W2325460018 @default.
• W222030266 cites W2330349737 @default.
• W222030266 cites W2340638737 @default.
• W222030266 cites W2418555921 @default.
• W222030266 cites W261581681 @default.
• W222030266 cites W3152388549 @default.
• W222030266 cites W5385768 @default.
• W222030266 hasPublicationYear "1995" @default.
• W222030266 type Work @default.
• W222030266 sameAs 222030266 @default.
• W222030266 citedByCount "0" @default.
• W222030266 crossrefType "journal-article" @default.
• W222030266 hasAuthorship W222030266A5004956623 @default.
• W222030266 hasAuthorship W222030266A5048908501 @default.
• W222030266 hasAuthorship W222030266A5068343035 @default.
• W222030266 hasAuthorship W222030266A5075389112 @default.
• W222030266 hasAuthorship W222030266A5083909396 @default.
• W222030266 hasAuthorship W222030266A5089213415 @default.
• W222030266 hasAuthorship W222030266A5089591844 @default.
• W222030266 hasConcept C126322002 @default.
• W222030266 hasConcept C134018914 @default.
• W222030266 hasConcept C164705383 @default.
• W222030266 hasConcept C185592680 @default.
• W222030266 hasConcept C203014093 @default.
• W222030266 hasConcept C2777292125 @default.
• W222030266 hasConcept C2777785093 @default.
• W222030266 hasConcept C2779581417 @default.
• W222030266 hasConcept C2780868729 @default.
• W222030266 hasConcept C3018697912 @default.
• W222030266 hasConcept C3018972837 @default.
• W222030266 hasConcept C500558357 @default.
• W222030266 hasConcept C54173615 @default.
• W222030266 hasConcept C71924100 @default.
• W222030266 hasConcept C89560881 @default.
• W222030266 hasConceptScore W222030266C126322002 @default.
• W222030266 hasConceptScore W222030266C134018914 @default.
• W222030266 hasConceptScore W222030266C164705383 @default.
• W222030266 hasConceptScore W222030266C185592680 @default.
• W222030266 hasConceptScore W222030266C203014093 @default.
• W222030266 hasConceptScore W222030266C2777292125 @default.
• W222030266 hasConceptScore W222030266C2777785093 @default.
• W222030266 hasConceptScore W222030266C2779581417 @default.
• W222030266 hasConceptScore W222030266C2780868729 @default.
• W222030266 hasConceptScore W222030266C3018697912 @default.
• W222030266 hasConceptScore W222030266C3018972837 @default.
• W222030266 hasConceptScore W222030266C500558357 @default.
• W222030266 hasConceptScore W222030266C54173615 @default.
• W222030266 hasConceptScore W222030266C71924100 @default.
• W222030266 hasConceptScore W222030266C89560881 @default.
• W222030266 hasLocation W2220302661 @default.
• W222030266 hasOpenAccess W222030266 @default.
• W222030266 hasPrimaryLocation W2220302661 @default.
• W222030266 hasRelatedWork W129080217 @default.
• W222030266 hasRelatedWork W1969497394 @default.
• W222030266 hasRelatedWork W1974456921 @default.
• W222030266 hasRelatedWork W1976128795 @default.
• W222030266 hasRelatedWork W1978999308 @default.
• W222030266 hasRelatedWork W1980404286 @default.
• W222030266 hasRelatedWork W1986884523 @default.
• W222030266 hasRelatedWork W2002191710 @default.
• W222030266 hasRelatedWork W2041846559 @default.
• W222030266 hasRelatedWork W2043674016 @default.
• W222030266 hasRelatedWork W2047261816 @default.

• next