FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2220325389> ?p ?o ?g. }

• W2220325389 endingPage "463" @default.
• W2220325389 startingPage "448" @default.
• W2220325389 abstract "Objective Cognitive impairments in Parkinson disease (PD) are thought to be caused in part by dopamine dysregulation. However, even when nigrostriatal dopamine neuron loss is severe enough to cause motor symptoms, many patients remain cognitively unimpaired. It is unclear what brain mechanisms allow these patients to remain cognitively unimpaired despite substantial dopamine dysregulation. Methods Thirty‐one cognitively unimpaired PD participants off dopaminergic medications were scanned using functional magnetic resonance imaging while they performed a working memory task, along with 23 controls. We first compared the PD off medication (PD_OFF) group with controls to determine whether PD participants engage compensatory frontostriatal mechanisms during working memory. We then studied the same PD participants on dopaminergic medications to determine whether these compensatory brain changes are altered with dopamine. Results Controls and PD showed working memory load‐dependent activation in the bilateral putamen, anterior–dorsal insula, supplementary motor area, and anterior cingulate cortex. Compared to controls, PD_OFF showed compensatory hyperactivation of bilateral putamen and posterior insula, and machine learning algorithms identified robust differences in putamen activation patterns. Compared to PD_OFF, the PD on medication group showed reduced compensatory activation in the putamen. Loss of compensatory hyperactivation on dopaminergic medication correlated with slower performance on the working memory task and slower cognitive speed on the Symbol Digit Modality Test. Interpretation Our results provide novel evidence that PD patients maintain normal cognitive performance through compensatory hyperactivation of the putamen. Dopaminergic medication downregulates this hyperactivation, and the degree of downregulation predicts behavior. Identifying cognitive compensatory mechanisms in PD is important for understanding how some patients maintain intact cognitive performance despite nigrostriatal dopamine loss. ANN NEUROL 2016;79:448–463" @default.
• W2220325389 created "2016-06-24" @default.
• W2220325389 creator A5013022781 @default.
• W2220325389 creator A5036363667 @default.
• W2220325389 creator A5053689920 @default.
• W2220325389 creator A5072595126 @default.
• W2220325389 creator A5073465507 @default.
• W2220325389 creator A5076697411 @default.
• W2220325389 creator A5083128550 @default.
• W2220325389 creator A5091625990 @default.
• W2220325389 date "2016-02-10" @default.
• W2220325389 modified "2023-10-16" @default.
• W2220325389 title "Compensatory neural mechanisms in cognitively unimpaired <scp>P</scp> arkinson disease" @default.
• W2220325389 cites W1584748823 @default.
• W2220325389 cites W1672024307 @default.
• W2220325389 cites W1723704394 @default.
• W2220325389 cites W1805914682 @default.
• W2220325389 cites W1921280105 @default.
• W2220325389 cites W1950204396 @default.
• W2220325389 cites W1964320082 @default.
• W2220325389 cites W1965854629 @default.
• W2220325389 cites W1965959650 @default.
• W2220325389 cites W1974734995 @default.
• W2220325389 cites W1980436365 @default.
• W2220325389 cites W1982473227 @default.
• W2220325389 cites W1987003014 @default.
• W2220325389 cites W1994357188 @default.
• W2220325389 cites W1995216385 @default.
• W2220325389 cites W1996507113 @default.
• W2220325389 cites W1997538961 @default.
• W2220325389 cites W2003119385 @default.
• W2220325389 cites W2011717274 @default.
• W2220325389 cites W2015360607 @default.
• W2220325389 cites W2017562658 @default.
• W2220325389 cites W2020125528 @default.
• W2220325389 cites W2025831911 @default.
• W2220325389 cites W2043806828 @default.
• W2220325389 cites W2053974283 @default.
• W2220325389 cites W2053988321 @default.
• W2220325389 cites W2060881658 @default.
• W2220325389 cites W2062104106 @default.
• W2220325389 cites W2066785847 @default.
• W2220325389 cites W2069804653 @default.
• W2220325389 cites W2094134651 @default.
• W2220325389 cites W2096707172 @default.
• W2220325389 cites W2102139723 @default.
• W2220325389 cites W2106935339 @default.
• W2220325389 cites W2108310775 @default.
• W2220325389 cites W2108510083 @default.
• W2220325389 cites W2114110854 @default.
• W2220325389 cites W2115031259 @default.
• W2220325389 cites W2120049868 @default.
• W2220325389 cites W2124949530 @default.
• W2220325389 cites W2127645750 @default.
• W2220325389 cites W2129624700 @default.
• W2220325389 cites W2131434127 @default.
• W2220325389 cites W2140978740 @default.
• W2220325389 cites W2143726556 @default.
• W2220325389 cites W2155090627 @default.
• W2220325389 cites W2156013560 @default.
• W2220325389 cites W2162301844 @default.
• W2220325389 cites W2163324586 @default.
• W2220325389 cites W2166524215 @default.
• W2220325389 cites W2169579059 @default.
• W2220325389 cites W2171938789 @default.
• W2220325389 cites W51969893 @default.
• W2220325389 doi "https://doi.org/10.1002/ana.24585" @default.
• W2220325389 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4789131" @default.
• W2220325389 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26696272" @default.
• W2220325389 hasPublicationYear "2016" @default.
• W2220325389 type Work @default.
• W2220325389 sameAs 2220325389 @default.
• W2220325389 citedByCount "57" @default.
• W2220325389 countsByYear W22203253892016 @default.
• W2220325389 countsByYear W22203253892017 @default.
• W2220325389 countsByYear W22203253892018 @default.
• W2220325389 countsByYear W22203253892019 @default.
• W2220325389 countsByYear W22203253892020 @default.
• W2220325389 countsByYear W22203253892021 @default.
• W2220325389 countsByYear W22203253892022 @default.
• W2220325389 countsByYear W22203253892023 @default.
• W2220325389 crossrefType "journal-article" @default.
• W2220325389 hasAuthorship W2220325389A5013022781 @default.
• W2220325389 hasAuthorship W2220325389A5036363667 @default.
• W2220325389 hasAuthorship W2220325389A5053689920 @default.
• W2220325389 hasAuthorship W2220325389A5072595126 @default.
• W2220325389 hasAuthorship W2220325389A5073465507 @default.
• W2220325389 hasAuthorship W2220325389A5076697411 @default.
• W2220325389 hasAuthorship W2220325389A5083128550 @default.
• W2220325389 hasAuthorship W2220325389A5091625990 @default.
• W2220325389 hasBestOaLocation W22203253891 @default.
• W2220325389 hasConcept C126322002 @default.
• W2220325389 hasConcept C137183658 @default.
• W2220325389 hasConcept C15744967 @default.
• W2220325389 hasConcept C169760540 @default.
• W2220325389 hasConcept C169900460 @default.
• W2220325389 hasConcept C21963081 @default.
• W2220325389 hasConcept C2778366672 @default.

• next