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- W2220357450 abstract "Abstract A method for precise, minute-to-minute measurement of gastric acid output in the rat is described. In the anesthetized rat, the stomach is opened and clamped in a chamber connected by recirculating pump to a pH-stat titrating apparatus. Addition of acid to the mucosal chamber is detected within a few seconds, the titration of the acid is completed within 1 minute. Basal acid secretion is usual and the preparation demonstrates appropriate response to the secretory stimulants gastrin pentapeptide, histamine, and methacholine; further, acetazolamide is shown to inhibit pentagastrin-induced secretory stimulation and atropine inhibits that due to methacholine. Maintenance of secretion for up to 8 hours permits trials of several doses of an agent or of several agents during one study." @default.
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- W2220357450 date "1973-06-01" @default.
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- W2220357450 title "Continuous recording of gastric acid output in the rat." @default.
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