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- W2220373516 abstract "This chapter discusses the biological interactions taking place at a liquid–solid interface. The investigated reactions presented in the chapter are of two kinds: (1) the interactions of adsorbed layers of antigen, protein, or polysaccharide, with antibodies present in solutions into which the antigen-coated slides were immersed and (2) proteolytic action of trypsin on adsorbed layers of susceptible substrate. The chapter describes the experiments that are involved in the interaction of protein or polysaccharide molecules adsorbed on the surface of a slide with molecules of antibodies or enzymes in solution. Specific interaction between antigens and antibodies takes place in definite multiple proportions, that is, in stoichiometric ratios, and no covalent bonds are involved. A definite long-range order of antigen molecules adsorbed on a slide permits a long-range interaction with antibody molecules, which does not require contacts between antigen and antibody. Only in the past few years has it been possible to demonstrate experimentally the fact that antibodies can be specifically immobilized on a membrane separating them from adsorbed underlying antigen molecules. In vivo long-range interactions might arise from cooperation between molecules condensed with long-range order in view of the prevalence of interface at many levels of organization." @default.
- W2220373516 created "2016-06-24" @default.
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- W2220373516 date "1982-01-01" @default.
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- W2220373516 title "Biological Interactions Taking Place at a Liquid-Solid Interface" @default.
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- W2220373516 doi "https://doi.org/10.1016/s0074-7696(08)60372-1" @default.
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