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- W2220440138 abstract "To study the incidence of Rotavirus and Norovirus diarrhea, their serogroups, genotypes and to compare disease severity between them. Cross sectional study. Tertiary Care Centre. All children less than 60 months of having diarrhea as defined by WHO. Children having bacterial diarrhea after clinical and lab evaluation were excluded. Fresh stool samples were subjected to microscopy followed by ELISA. The positive samples were stored at -20°C for further RNA extraction and genotyping. Rotavirus positive samples were further sub-typed by genotyping in RT-PCR. Samples found negative on ELISA were electropherotyped to detect rotavirus escaping ELISA and those found positive are further genotyped. Rotavirus negative samples were subjected to Norovirus ELISA. These subtypes were clinically correlated in terms of disease severity on the basis of modified 20 point Vesikari score. Of total 226 patients with diarrhea screened, 56 were excluded. 170 patients were enrolled in the study with mean age of 23.35 months and male predominance (56%). Other associated symptoms were vomitings (29%), fever (14%), cough (14%), breathlessness (5%), and lethargy (3%). 22 (13%) were positive for Rotavirus, 10 patients by ELISA and additional 12 by electropherotyping. Out of 22, 19 were of long arm pherotype type, 1 short arm pherotype and 2 mixed type. Norovirus was found positive in 7 (7.7%) out of 90 patients. Rotavirus diarrhea is significantly (P = .04) present in younger age (18.7 months) as compared to non-rotaviral diarrhea (24 months). Frequency of stool and duration of illness is significantly (P = <.001) more in rotavirus diarrhea (9.6 times/day and 7 days) as compared to nonrotaviral diarrhea (7.6 times/day and 5.4 days). Disease severity was more in rotaviral diarrhea than nonrotaviral by vesikari scoring, whereas norovirus diarrhea was mildest. Incidence of rotavirus and norovirus diarrhea is 13% and 7.7% respectively. Rotavirus causes the more severe diarrhea with increased rate of dehydration and longer duration of illness as compared to nonrotaviral diarrhea." @default.
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- W2220440138 date "2015-07-01" @default.
- W2220440138 modified "2023-09-26" @default.
- W2220440138 title "Incidence, Serogroups and Genotypes of Rotavirus and Norovirus Causing Acute Diarrhea and to Compare Their Disease Severity, Estimated From a Prospective Study in Mumbai, India" @default.
- W2220440138 doi "https://doi.org/10.1016/j.cgh.2015.04.048" @default.
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