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- W2220502499 abstract "The production of extracellular polysaccharide (EPS) molecules is a common feature of many bacteria (Whitfield and Valvano, 1993; Roberts, 1996). These molecules may be linked to the cell surface and organized into a discrete structure termed the capsule or, alternatively, may comprise an amorphous slime layer that is easily sloughed off from the cell surface. In essence, EPS provides a hydrated negatively charged gel that surrounds the bacterium and it is the physicochemical properties of this gel that account for the biological properties of bacterial capsules. A striking feature of bacterial capsular polysaccharides is their diversity, both in terms of component sugars and the glycosidic bond between repeating sugar residues. Even within a single bacterial species, there can be enormous structural diversity. For instance, in the case of Streptococcus pneumoniae there are in excess of 90 capsular serotypes. This diversity has important implications for the design of vaccine formulations that are based on capsular polysaccharides. Paradoxically, amongst this array of structural diversity, there are capsular polysaccharide molecules that are conserved across different bacterial species, such as the Escherichia coli K1 and Neisseria meningitidis serogroup B capsular polysaccharide (Jennings, 1990). Both the diversity of capsular polysaccharides and the conservation of certain polysaccharide structures across species barriers raise questions about the evolution of capsule gene clusters and the selective pressures that drive structural diversity." @default.
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- W2220502499 date "2002-03-14" @default.
- W2220502499 modified "2023-10-18" @default.
- W2220502499 title "Regulation of capsule expression" @default.
- W2220502499 doi "https://doi.org/10.1017/cbo9780511541575.006" @default.
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