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- W2220725156 abstract "Introduction: Reactivation of a stabilized memory induces a second wave of consolidation processwhich is now called as reconsolidation. Recently, a late consolidation process was proposed, suggesting thatmemory after learning within a delayed time window was labile. This late memory consolidation needsprotein synthesis in the hippocampus. The aim of this study was to test whether the re-stabilized memoryafter reactivation also requires a late-phase protein synthesis in the hippocampus. We also investigatedwhether memories become increasingly resistant to disruption with age.Materials and Methods: Male Wistar rats were trained in a one trial passive avoidance task (1mA, 3s).In the first experiment, cycloheximide (CYC, 2.8 mg/kg, i.p.) administrated 15 minutes before the memoryreactivation and also 3, 6, 12 and 24 hours after the memory reactivation. In the second experiment, thesame dose of CYC administrated to rats with memory age of 7, 14, 28 or 56 days. In the third experiment,CYC administrated (4 μg or 8μg/μl) into hippocampus. In the last experiment, CYC administrated (8μg/μl)into hippocampus of rats with memory age of 7, 14, 28 or 56 days. In all experiments, memory test wasdone 2 and 7 days after memory reactivation.Results: Results indicated that systemic administration of CYC only 12h after memory reactivationsignificantly impaired memory retention. With increasing the age of memory, no effect of CYC was found.This impairing effect also was found when CYC was injected into hippocampus. This impairing effect alsowas found on memory age with 7 days.Conclusion: Our findings indicate that protein synthesis, particularly in the hippocampus, plays animportant role in the late memory reconsolidation and with increasing the age of memories, they becomeresistant to disruption.Keywords: Protein synthesis, Cycloheximide, Dorsal hippocampus, Late memory reconsolidation,Passive avoidance task." @default.
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- W2220725156 date "2015-04-10" @default.
- W2220725156 modified "2023-09-28" @default.
- W2220725156 title "Effects of systemic and intra-hippocampal injections of cycloheximide on the late reconsolidation of fear-based memory in rats" @default.
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