Matches in SemOpenAlex for { <https://semopenalex.org/work/W2220762819> ?p ?o ?g. }
- W2220762819 endingPage "e0139990" @default.
- W2220762819 startingPage "e0139990" @default.
- W2220762819 abstract "Androgen receptor (AR) mediated signalling is necessary for normal development of the prostate gland and also drives prostate cancer (PCa) cell growth and survival, with many studies showing a correlation between increased receptor levels and therapy resistance with progression to fatal castrate recurrent PCa (CRPC). Although it has been held for some time that the transcription factor Sp1 is the main stimulator of AR gene transcription, comprehensive knowledge of the regulation of the AR gene remains incomplete. Here we describe and characterise in detail two novel active regulatory elements in the 5'UTR of the human AR gene. Both of these elements contain overlapping binding sites for the positive transcription factor Sp1 and the repressor protein pur-α. Aberrant cell signalling is characteristic of PCa and the transcriptional activity of the AR promoter in PCa cells is dependent upon the relative amounts of the two transcription factors. Together with our corroboration of the dominant role of Sp1, the findings support the rationale of targeting this transcription factor to inhibit tumour progression. This should be of particular therapeutic relevance in CRPC where the levels of the repressor pur-α are reduced." @default.
- W2220762819 created "2016-06-24" @default.
- W2220762819 creator A5043472105 @default.
- W2220762819 creator A5056247791 @default.
- W2220762819 creator A5069421153 @default.
- W2220762819 creator A5085013845 @default.
- W2220762819 date "2015-10-08" @default.
- W2220762819 modified "2023-10-17" @default.
- W2220762819 title "An Sp1 Modulated Regulatory Region Unique to Higher Primates Regulates Human Androgen Receptor Promoter Activity in Prostate Cancer Cells" @default.
- W2220762819 cites W1581478432 @default.
- W2220762819 cites W1964548101 @default.
- W2220762819 cites W1966010244 @default.
- W2220762819 cites W1976284211 @default.
- W2220762819 cites W1981416792 @default.
- W2220762819 cites W1990353372 @default.
- W2220762819 cites W1993243592 @default.
- W2220762819 cites W1995103673 @default.
- W2220762819 cites W1996916516 @default.
- W2220762819 cites W1996956937 @default.
- W2220762819 cites W1998691242 @default.
- W2220762819 cites W1998889059 @default.
- W2220762819 cites W2000460499 @default.
- W2220762819 cites W2004344128 @default.
- W2220762819 cites W2006352011 @default.
- W2220762819 cites W2013433656 @default.
- W2220762819 cites W2015317618 @default.
- W2220762819 cites W2021051883 @default.
- W2220762819 cites W2025739622 @default.
- W2220762819 cites W2029420392 @default.
- W2220762819 cites W2037653294 @default.
- W2220762819 cites W2043537095 @default.
- W2220762819 cites W2044013736 @default.
- W2220762819 cites W2055917202 @default.
- W2220762819 cites W2059433128 @default.
- W2220762819 cites W2059586182 @default.
- W2220762819 cites W2064293531 @default.
- W2220762819 cites W2080053060 @default.
- W2220762819 cites W2081365151 @default.
- W2220762819 cites W2083204707 @default.
- W2220762819 cites W2085041013 @default.
- W2220762819 cites W2089518544 @default.
- W2220762819 cites W2100039734 @default.
- W2220762819 cites W2103201026 @default.
- W2220762819 cites W2105623411 @default.
- W2220762819 cites W2109773265 @default.
- W2220762819 cites W2110720974 @default.
- W2220762819 cites W2119391023 @default.
- W2220762819 cites W2119491276 @default.
- W2220762819 cites W2119752676 @default.
- W2220762819 cites W2126432659 @default.
- W2220762819 cites W2128251898 @default.
- W2220762819 cites W2128753121 @default.
- W2220762819 cites W2129312985 @default.
- W2220762819 cites W2132051411 @default.
- W2220762819 cites W2138885835 @default.
- W2220762819 cites W2140777784 @default.
- W2220762819 cites W2141255350 @default.
- W2220762819 cites W2142042137 @default.
- W2220762819 cites W2145069530 @default.
- W2220762819 cites W2145137051 @default.
- W2220762819 cites W2148416479 @default.
- W2220762819 cites W2164092182 @default.
- W2220762819 cites W2169489936 @default.
- W2220762819 cites W79483553 @default.
- W2220762819 doi "https://doi.org/10.1371/journal.pone.0139990" @default.
- W2220762819 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4598089" @default.
- W2220762819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26448047" @default.
- W2220762819 hasPublicationYear "2015" @default.
- W2220762819 type Work @default.
- W2220762819 sameAs 2220762819 @default.
- W2220762819 citedByCount "15" @default.
- W2220762819 countsByYear W22207628192016 @default.
- W2220762819 countsByYear W22207628192017 @default.
- W2220762819 countsByYear W22207628192018 @default.
- W2220762819 countsByYear W22207628192019 @default.
- W2220762819 countsByYear W22207628192020 @default.
- W2220762819 countsByYear W22207628192021 @default.
- W2220762819 countsByYear W22207628192023 @default.
- W2220762819 crossrefType "journal-article" @default.
- W2220762819 hasAuthorship W2220762819A5043472105 @default.
- W2220762819 hasAuthorship W2220762819A5056247791 @default.
- W2220762819 hasAuthorship W2220762819A5069421153 @default.
- W2220762819 hasAuthorship W2220762819A5085013845 @default.
- W2220762819 hasBestOaLocation W22207628191 @default.
- W2220762819 hasConcept C101762097 @default.
- W2220762819 hasConcept C104317684 @default.
- W2220762819 hasConcept C121608353 @default.
- W2220762819 hasConcept C138885662 @default.
- W2220762819 hasConcept C150194340 @default.
- W2220762819 hasConcept C158448853 @default.
- W2220762819 hasConcept C165864922 @default.
- W2220762819 hasConcept C179926584 @default.
- W2220762819 hasConcept C2780192828 @default.
- W2220762819 hasConcept C41895202 @default.
- W2220762819 hasConcept C502942594 @default.
- W2220762819 hasConcept C54355233 @default.
- W2220762819 hasConcept C57467964 @default.
- W2220762819 hasConcept C61367390 @default.