Matches in SemOpenAlex for { <https://semopenalex.org/work/W2220783465> ?p ?o ?g. }
- W2220783465 abstract "Mitochondrial damage and declines in ATP levels have been recently attributed to sertraline. The effects of sertraline on different parameters were investigated in washed platelets from 18 healthy male volunteers, after 24h of drug exposure. Sertraline toxicity was observed only at the highest concentrations, 30 and 100 μM, which significantly reduced platelet viability to 76 ± 3% and 20 ± 2%, respectively. The same concentrations significantly decreased total ATP to 73 ± 3% and 13 ± 2%, respectively. Basal values of glycogen were not significantly affected by sertraline treatment. Glutamate uptake was significantly reduced after treatment with 3, 30 and 100 μM, by 28 ± 6%, 32 ± 5% and 54 ± 4%, respectively. Our data showed that sertraline at therapeutic concentrations does not compromise platelet viability and ATP levels, but they suggest that in a situation where extracellular glutamate levels are potentially increased, sertraline might aggravate an excitotoxic condition." @default.
- W2220783465 created "2016-06-24" @default.
- W2220783465 creator A5012579358 @default.
- W2220783465 creator A5031517899 @default.
- W2220783465 creator A5035192779 @default.
- W2220783465 creator A5055042343 @default.
- W2220783465 date "2015-12-01" @default.
- W2220783465 modified "2023-09-29" @default.
- W2220783465 title "Sertraline reduces glutamate uptake in human platelets" @default.
- W2220783465 cites W1515331242 @default.
- W2220783465 cites W1533853049 @default.
- W2220783465 cites W1535612064 @default.
- W2220783465 cites W1578402817 @default.
- W2220783465 cites W1866745761 @default.
- W2220783465 cites W1969656642 @default.
- W2220783465 cites W1969914617 @default.
- W2220783465 cites W1979207531 @default.
- W2220783465 cites W1983388523 @default.
- W2220783465 cites W1985081477 @default.
- W2220783465 cites W1986484580 @default.
- W2220783465 cites W1994651650 @default.
- W2220783465 cites W2000353278 @default.
- W2220783465 cites W2002623292 @default.
- W2220783465 cites W2027417871 @default.
- W2220783465 cites W2027608279 @default.
- W2220783465 cites W2030291053 @default.
- W2220783465 cites W2034832966 @default.
- W2220783465 cites W2035578288 @default.
- W2220783465 cites W2035587882 @default.
- W2220783465 cites W2043368374 @default.
- W2220783465 cites W2043487786 @default.
- W2220783465 cites W2057710656 @default.
- W2220783465 cites W2062465486 @default.
- W2220783465 cites W2062931149 @default.
- W2220783465 cites W2063443054 @default.
- W2220783465 cites W2064376944 @default.
- W2220783465 cites W2070176743 @default.
- W2220783465 cites W2071735814 @default.
- W2220783465 cites W2074152887 @default.
- W2220783465 cites W2088141983 @default.
- W2220783465 cites W2088749504 @default.
- W2220783465 cites W2089227889 @default.
- W2220783465 cites W2091324069 @default.
- W2220783465 cites W2093570500 @default.
- W2220783465 cites W2097746233 @default.
- W2220783465 cites W2119774379 @default.
- W2220783465 cites W2140934918 @default.
- W2220783465 cites W2141731191 @default.
- W2220783465 cites W2149497936 @default.
- W2220783465 cites W2153915394 @default.
- W2220783465 cites W2157037483 @default.
- W2220783465 cites W2162652910 @default.
- W2220783465 cites W2169865323 @default.
- W2220783465 cites W2170495663 @default.
- W2220783465 cites W2171194568 @default.
- W2220783465 cites W3021092633 @default.
- W2220783465 doi "https://doi.org/10.1016/j.neuro.2015.10.014" @default.
- W2220783465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26529290" @default.
- W2220783465 hasPublicationYear "2015" @default.
- W2220783465 type Work @default.
- W2220783465 sameAs 2220783465 @default.
- W2220783465 citedByCount "7" @default.
- W2220783465 countsByYear W22207834652016 @default.
- W2220783465 countsByYear W22207834652017 @default.
- W2220783465 countsByYear W22207834652019 @default.
- W2220783465 countsByYear W22207834652020 @default.
- W2220783465 countsByYear W22207834652022 @default.
- W2220783465 countsByYear W22207834652023 @default.
- W2220783465 crossrefType "journal-article" @default.
- W2220783465 hasAuthorship W2220783465A5012579358 @default.
- W2220783465 hasAuthorship W2220783465A5031517899 @default.
- W2220783465 hasAuthorship W2220783465A5035192779 @default.
- W2220783465 hasAuthorship W2220783465A5055042343 @default.
- W2220783465 hasConcept C126322002 @default.
- W2220783465 hasConcept C134018914 @default.
- W2220783465 hasConcept C170493617 @default.
- W2220783465 hasConcept C185592680 @default.
- W2220783465 hasConcept C2777499176 @default.
- W2220783465 hasConcept C2777669559 @default.
- W2220783465 hasConcept C2779177272 @default.
- W2220783465 hasConcept C2781161787 @default.
- W2220783465 hasConcept C29730261 @default.
- W2220783465 hasConcept C55493867 @default.
- W2220783465 hasConcept C61174792 @default.
- W2220783465 hasConcept C71924100 @default.
- W2220783465 hasConcept C89560881 @default.
- W2220783465 hasConcept C98274493 @default.
- W2220783465 hasConceptScore W2220783465C126322002 @default.
- W2220783465 hasConceptScore W2220783465C134018914 @default.
- W2220783465 hasConceptScore W2220783465C170493617 @default.
- W2220783465 hasConceptScore W2220783465C185592680 @default.
- W2220783465 hasConceptScore W2220783465C2777499176 @default.
- W2220783465 hasConceptScore W2220783465C2777669559 @default.
- W2220783465 hasConceptScore W2220783465C2779177272 @default.
- W2220783465 hasConceptScore W2220783465C2781161787 @default.
- W2220783465 hasConceptScore W2220783465C29730261 @default.
- W2220783465 hasConceptScore W2220783465C55493867 @default.
- W2220783465 hasConceptScore W2220783465C61174792 @default.
- W2220783465 hasConceptScore W2220783465C71924100 @default.
- W2220783465 hasConceptScore W2220783465C89560881 @default.