FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2220786029> ?p ?o ?g. }

• W2220786029 endingPage "e0145608" @default.
• W2220786029 startingPage "e0145608" @default.
• W2220786029 abstract "Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) belongs to the steroid/thyroid hormone receptor superfamily and may contribute to the pathogenesis of obesity. It has not conclusively been established, however, whether its role is pro- or anti-adipogenic.Gene silencing of Coup-tfII in 3T3-F442A preadipocytes resulted in enhanced differentiation into mature adipocytes. This was associated with upregulation of the Notch signaling target gene Hey1. A functional role of Hey1 was confirmed by gene silencing in 3T3-F442A preadipocytes, resulting in impaired differentiation. In vivo, de novo fat pad formation in NUDE mice was significantly stimulated following injection of preadipocytes with Coup-tfII gene silencing, but impaired with Hey1 gene silencing. Moreover, expression of Coup-tfII was lower and that of Hey1 higher in isolated adipocytes of obese as compared to lean adipose tissue.These in vitro and in vivo data support an anti-adipogenic role of COUP-TFII via downregulating the Notch signaling target gene Hey1." @default.
• W2220786029 created "2016-06-24" @default.
• W2220786029 creator A5015282498 @default.
• W2220786029 creator A5017438245 @default.
• W2220786029 creator A5019162161 @default.
• W2220786029 creator A5058575542 @default.
• W2220786029 date "2015-12-31" @default.
• W2220786029 modified "2023-09-24" @default.
• W2220786029 title "The Anti-Adipogenic Potential of COUP-TFII Is Mediated by Downregulation of the Notch Target Gene Hey1" @default.
• W2220786029 cites W1503290844 @default.
• W2220786029 cites W1973227211 @default.
• W2220786029 cites W1981440485 @default.
• W2220786029 cites W1991866614 @default.
• W2220786029 cites W1994920666 @default.
• W2220786029 cites W1995810876 @default.
• W2220786029 cites W2006717309 @default.
• W2220786029 cites W2007257071 @default.
• W2220786029 cites W2011869493 @default.
• W2220786029 cites W2014426248 @default.
• W2220786029 cites W2018000037 @default.
• W2220786029 cites W2023271280 @default.
• W2220786029 cites W2034850328 @default.
• W2220786029 cites W2039063847 @default.
• W2220786029 cites W2061144747 @default.
• W2220786029 cites W2062240527 @default.
• W2220786029 cites W2063489655 @default.
• W2220786029 cites W2069649414 @default.
• W2220786029 cites W2070589179 @default.
• W2220786029 cites W2075221395 @default.
• W2220786029 cites W2076189503 @default.
• W2220786029 cites W2082528772 @default.
• W2220786029 cites W2085673152 @default.
• W2220786029 cites W2086876067 @default.
• W2220786029 cites W2096388724 @default.
• W2220786029 cites W2109557739 @default.
• W2220786029 cites W2123160276 @default.
• W2220786029 cites W2123534663 @default.
• W2220786029 cites W2124857894 @default.
• W2220786029 cites W2131785738 @default.
• W2220786029 cites W2131806711 @default.
• W2220786029 cites W2143873575 @default.
• W2220786029 doi "https://doi.org/10.1371/journal.pone.0145608" @default.
• W2220786029 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4697848" @default.
• W2220786029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26719988" @default.
• W2220786029 hasPublicationYear "2015" @default.
• W2220786029 type Work @default.
• W2220786029 sameAs 2220786029 @default.
• W2220786029 citedByCount "10" @default.
• W2220786029 countsByYear W22207860292016 @default.
• W2220786029 countsByYear W22207860292017 @default.
• W2220786029 countsByYear W22207860292018 @default.
• W2220786029 countsByYear W22207860292019 @default.
• W2220786029 countsByYear W22207860292021 @default.
• W2220786029 countsByYear W22207860292022 @default.
• W2220786029 countsByYear W22207860292023 @default.
• W2220786029 crossrefType "journal-article" @default.
• W2220786029 hasAuthorship W2220786029A5015282498 @default.
• W2220786029 hasAuthorship W2220786029A5017438245 @default.
• W2220786029 hasAuthorship W2220786029A5019162161 @default.
• W2220786029 hasAuthorship W2220786029A5058575542 @default.
• W2220786029 hasBestOaLocation W22207860291 @default.
• W2220786029 hasConcept C104317684 @default.
• W2220786029 hasConcept C119056186 @default.
• W2220786029 hasConcept C122927707 @default.
• W2220786029 hasConcept C126322002 @default.
• W2220786029 hasConcept C127561419 @default.
• W2220786029 hasConcept C134018914 @default.
• W2220786029 hasConcept C161879069 @default.
• W2220786029 hasConcept C171089720 @default.
• W2220786029 hasConcept C185592680 @default.
• W2220786029 hasConcept C502942594 @default.
• W2220786029 hasConcept C54355233 @default.
• W2220786029 hasConcept C62478195 @default.
• W2220786029 hasConcept C71924100 @default.
• W2220786029 hasConcept C86339819 @default.
• W2220786029 hasConcept C86803240 @default.
• W2220786029 hasConcept C95444343 @default.
• W2220786029 hasConceptScore W2220786029C104317684 @default.
• W2220786029 hasConceptScore W2220786029C119056186 @default.
• W2220786029 hasConceptScore W2220786029C122927707 @default.
• W2220786029 hasConceptScore W2220786029C126322002 @default.
• W2220786029 hasConceptScore W2220786029C127561419 @default.
• W2220786029 hasConceptScore W2220786029C134018914 @default.
• W2220786029 hasConceptScore W2220786029C161879069 @default.
• W2220786029 hasConceptScore W2220786029C171089720 @default.
• W2220786029 hasConceptScore W2220786029C185592680 @default.
• W2220786029 hasConceptScore W2220786029C502942594 @default.
• W2220786029 hasConceptScore W2220786029C54355233 @default.
• W2220786029 hasConceptScore W2220786029C62478195 @default.
• W2220786029 hasConceptScore W2220786029C71924100 @default.
• W2220786029 hasConceptScore W2220786029C86339819 @default.
• W2220786029 hasConceptScore W2220786029C86803240 @default.
• W2220786029 hasConceptScore W2220786029C95444343 @default.
• W2220786029 hasIssue "12" @default.
• W2220786029 hasLocation W22207860291 @default.
• W2220786029 hasLocation W22207860292 @default.
• W2220786029 hasLocation W22207860293 @default.
• W2220786029 hasLocation W22207860294 @default.

• next