FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2220838695> ?p ?o ?g. }

• W2220838695 endingPage "313" @default.
• W2220838695 startingPage "301" @default.
• W2220838695 abstract "M-protein and pyrogenic toxins are the most important virulence factors of Streptococcus pyogenes, and they play significant role in the pathophysiology of acute rheumatoid fever and scarlet fever, respectively. In this study, the pharyngeal carriage of S.pyogenes of the primary school children, clonal relationship of the strains, M-protein types, and the presence of pyrogenic toxin genes were aimed to be investigated. A total of 668 throat cultures obtained from children (age range: 6-16 years) in two primary schools in our region, were included in the study. The clonal relationships of the isolated group A streptococci (GAS) strains were investigated by DiversiLab assay (BioMérieux, France), and the clonal relatedness was confirmed by pulsed-field gel electrophoresis (PFGE) method. M-protein (emm) typing was performed by DNA sequencing as suggested by Centers for Disease Control and Prevention (CDC). The genes encoding pyrogenic toxins, speA and speC, were investigated by an in-house multiplex polymerase chain reaction (PCR) method. S.pyogenes was isolated from 134 (20.05%) of the throat samples. The GAS carriage rate of the students aged ≥10 was statistically higher than those 7-9 years age group (%22 vs %16.4, p<0.05). The M protein gene could be characterized only among 123 isolates by DNA sequencing, and 20 different emm types were detected. The most frequent emm type was emm1 (n=38, 30.9%) followed by emm12 (n=18, 14.6%), emm89 (n=10, 8.1%), emm118 (n=9, 7.3%), and emm4 (n=7, 5.7%). Pyrogenic toxin genes were found in 25 (18.6%) of the isolates, including speA in 11 isolates (8.2%) and speC in 12 isolates (8.9%) and both genes were detected in 2 isolates (1.5%). Sixty-two different Rep (Repetitive extragenic palindromic)-PCR profiles were detected in 134 S.pyogenes isolates by DiversiLab method. Thirteen different clusters were formed by a total of clonally related 36 isolates revealing a strain clustering ratio of 26.9%. Clonal relationship of all isolates in the same cluster was confirmed by PFGE method. In this study, relatively high percentage of GAS carriage was observed among primary school children in our region. The coverage rate of the 30-valent vaccine was determined to be over 90% with respect to M-protein types. Since the pyrogenic toxin-encoding genes were found in one fifth of the isolates from the studied subjects, we concluded that the carrier population may also have high risk for scarlet fever. We also concluded that, the clonal relationship ratio determined among the isolates may be a risk in school transmission of GAS." @default.
• W2220838695 created "2016-06-24" @default.
• W2220838695 creator A5028681627 @default.
• W2220838695 creator A5029634543 @default.
• W2220838695 creator A5034212254 @default.
• W2220838695 creator A5044174523 @default.
• W2220838695 creator A5072627456 @default.
• W2220838695 creator A5085856447 @default.
• W2220838695 date "2015-07-15" @default.
• W2220838695 modified "2023-09-26" @default.
• W2220838695 title "Carriage of Streptococcus pyogenes in Primary School Children: M-Protein Types, Pyrogenic Toxin Genes, and Investigation of the Clonal Relationships Between the Isolates" @default.
• W2220838695 doi "https://doi.org/10.5578/mb.9311" @default.
• W2220838695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26313273" @default.
• W2220838695 hasPublicationYear "2015" @default.
• W2220838695 type Work @default.
• W2220838695 sameAs 2220838695 @default.
• W2220838695 citedByCount "5" @default.
• W2220838695 countsByYear W22208386952018 @default.
• W2220838695 countsByYear W22208386952020 @default.
• W2220838695 countsByYear W22208386952022 @default.
• W2220838695 crossrefType "journal-article" @default.
• W2220838695 hasAuthorship W2220838695A5028681627 @default.
• W2220838695 hasAuthorship W2220838695A5029634543 @default.
• W2220838695 hasAuthorship W2220838695A5034212254 @default.
• W2220838695 hasAuthorship W2220838695A5044174523 @default.
• W2220838695 hasAuthorship W2220838695A5072627456 @default.
• W2220838695 hasAuthorship W2220838695A5085856447 @default.
• W2220838695 hasConcept C104317684 @default.
• W2220838695 hasConcept C105702510 @default.
• W2220838695 hasConcept C116084860 @default.
• W2220838695 hasConcept C135763542 @default.
• W2220838695 hasConcept C142724271 @default.
• W2220838695 hasConcept C153911025 @default.
• W2220838695 hasConcept C2776989088 @default.
• W2220838695 hasConcept C2777367657 @default.
• W2220838695 hasConcept C2778276568 @default.
• W2220838695 hasConcept C2779306812 @default.
• W2220838695 hasConcept C2779489039 @default.
• W2220838695 hasConcept C32762888 @default.
• W2220838695 hasConcept C42084846 @default.
• W2220838695 hasConcept C49105822 @default.
• W2220838695 hasConcept C523546767 @default.
• W2220838695 hasConcept C54355233 @default.
• W2220838695 hasConcept C60987743 @default.
• W2220838695 hasConcept C71924100 @default.
• W2220838695 hasConcept C86803240 @default.
• W2220838695 hasConcept C89423630 @default.
• W2220838695 hasConcept C90583042 @default.
• W2220838695 hasConceptScore W2220838695C104317684 @default.
• W2220838695 hasConceptScore W2220838695C105702510 @default.
• W2220838695 hasConceptScore W2220838695C116084860 @default.
• W2220838695 hasConceptScore W2220838695C135763542 @default.
• W2220838695 hasConceptScore W2220838695C142724271 @default.
• W2220838695 hasConceptScore W2220838695C153911025 @default.
• W2220838695 hasConceptScore W2220838695C2776989088 @default.
• W2220838695 hasConceptScore W2220838695C2777367657 @default.
• W2220838695 hasConceptScore W2220838695C2778276568 @default.
• W2220838695 hasConceptScore W2220838695C2779306812 @default.
• W2220838695 hasConceptScore W2220838695C2779489039 @default.
• W2220838695 hasConceptScore W2220838695C32762888 @default.
• W2220838695 hasConceptScore W2220838695C42084846 @default.
• W2220838695 hasConceptScore W2220838695C49105822 @default.
• W2220838695 hasConceptScore W2220838695C523546767 @default.
• W2220838695 hasConceptScore W2220838695C54355233 @default.
• W2220838695 hasConceptScore W2220838695C60987743 @default.
• W2220838695 hasConceptScore W2220838695C71924100 @default.
• W2220838695 hasConceptScore W2220838695C86803240 @default.
• W2220838695 hasConceptScore W2220838695C89423630 @default.
• W2220838695 hasConceptScore W2220838695C90583042 @default.
• W2220838695 hasIssue "3" @default.
• W2220838695 hasLocation W22208386951 @default.
• W2220838695 hasLocation W22208386952 @default.
• W2220838695 hasOpenAccess W2220838695 @default.
• W2220838695 hasPrimaryLocation W22208386951 @default.
• W2220838695 hasRelatedWork W1869488844 @default.
• W2220838695 hasRelatedWork W2008173201 @default.
• W2220838695 hasRelatedWork W2074826652 @default.
• W2220838695 hasRelatedWork W2084807013 @default.
• W2220838695 hasRelatedWork W2110934799 @default.
• W2220838695 hasRelatedWork W2129349228 @default.
• W2220838695 hasRelatedWork W2152574511 @default.
• W2220838695 hasRelatedWork W2531360370 @default.
• W2220838695 hasRelatedWork W2951824857 @default.
• W2220838695 hasRelatedWork W3030617837 @default.
• W2220838695 hasVolume "49" @default.
• W2220838695 isParatext "false" @default.
• W2220838695 isRetracted "false" @default.
• W2220838695 magId "2220838695" @default.
• W2220838695 workType "article" @default.