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- W2220847897 endingPage "57" @default.
- W2220847897 startingPage "43" @default.
- W2220847897 abstract "Human mesenchymal stem cells (hMSCs) have emerged as an important cell type in cell therapy and tissue engineering. In these applications, maintaining the therapeutic properties of hMSCs requires tight control of the culture environments and the structural cell organizations. Bioreactor systems are essential tools to achieve these goals in the clinical-scale expansion and tissue engineering applications. This review summarizes how different bioreactors provide cues to regulate the structure and the chemico-mechanical microenvironment of hMSCs with a focus on 3D organization. In addition to conventional bioreactors, recent advances in microfluidic bioreactors as a novel approach to better control the hMSC microenvironment are also discussed. These advancements highlight the key role of bioreactor systems in preserving hMSC's functional properties by providing dynamic and temporal regulation of in vitro cellular microenvironment." @default.
- W2220847897 created "2016-06-24" @default.
- W2220847897 creator A5016503289 @default.
- W2220847897 creator A5032024543 @default.
- W2220847897 creator A5056747537 @default.
- W2220847897 creator A5059852869 @default.
- W2220847897 date "2015-12-23" @default.
- W2220847897 modified "2023-09-30" @default.
- W2220847897 title "Regulation of mesenchymal stem cell 3D microenvironment: From macro to microfluidic bioreactors" @default.
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