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- W222103681 abstract "This introductory article for the Epigenetic section of the Encyclopedia of Human Biology places the discipline of epigenetics into its wider context of genetics to which it genuinely belongs. The mechanisms operative in epigenetics have far reaching implications for many fields of biology but are all dependent on DNA and its interactions with proteins and RNA. The term epigenetics is misleading since it might be misunderstood to relate to events outside or above (ɛ'πι-) genetics, which is definitely not the case. Nevertheless, the name epigenetics has been widely applied in the biomedical literature with the implicit, though not always explicitly mentioned, caveat that “epigenetics is just a different way of looking at genetics.” The contributions in the Epigenetics Section of the Encyclopedia address a wide range of topics in biomedical research. This introductory article relates to the early history of the field, mainly on DNA methylation. In addition, this article also considers the growing importance of nucleotide sequences in between genes which have recently been highlighted in the ENCODE project. In these analyses, numerous DNA motifs and sites for protein interactions have been identified. This project has mainly relied on biostatistical methods. It is still unproven, whether the actual functional meaning of DNA motifs in intact genomes can be reliably deduced from the results of reconstruction experiments. Undoubtedly, studies on the multifactorial regulation of gene expression – transcriptional or posttranscriptional – in different cells of an organism or in different organisms will continue to occupy biomedical research for many years, regardless of the name one applied to this field of research." @default.
- W222103681 created "2016-06-24" @default.
- W222103681 creator A5020094417 @default.
- W222103681 date "2014-01-01" @default.
- W222103681 modified "2023-09-27" @default.
- W222103681 title "Epigenetics" @default.
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- W222103681 doi "https://doi.org/10.1016/b978-0-12-801238-3.00091-x" @default.
- W222103681 hasPublicationYear "2014" @default.
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