FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2221165617> ?p ?o ?g. }

• W2221165617 endingPage "23" @default.
• W2221165617 startingPage "14" @default.
• W2221165617 abstract "Studies have provided evidence of heterogeneity within chronic fatigue syndrome (CFS), but few have used data from large cohorts of CFS patients or replication samples.29 UK secondary-care CFS services recorded the presence/absence of 12 CFS-related symptoms; 8 of these symptoms were recorded by a Dutch tertiary service. Latent Class Analysis (LCA) was used to assign symptom profiles (phenotypes). Regression models were fitted with phenotype as outcome (in relation to age, sex, BMI, duration of illness) and exposure (in relation to comorbidities and patient-reported measures).Data were available for 7041 UK and 1392 Dutch patients. Almost all patients in both cohorts presented with post-exertional malaise, cognitive dysfunction and disturbed/unrefreshing sleep, and these 3 symptoms were excluded from LCA. In UK patients, six phenotypes emerged: 'full' polysymptomatic (median 8, IQR 7-9 symptoms) 32.8%; 'pain-only' (muscle/joint) 20.3%; 'sore throat/painful lymph node' 4.5%; and 'oligosymptomatic' (median 1, IQR 0-2 symptoms) 4.7%. Two 'partial' polysymptomatic phenotypes were similar to the 'full' phenotype, bar absence of dizziness/nausea/palpitations (21.4%) or sore throat/painful lymph nodes (16.3%). Women and patients with longer duration of illness were more likely to be polysymptomatic. Polysymptomatic patients had more severe illness and more comorbidities. LCA restricted to 5 symptoms recorded in both cohorts indicated 3 classes (polysymptomatic, oligosymptomatic, pain-only), which were replicated in Dutch data.Adults with CFS may have one of 6 symptom-based phenotypes associated with sex, duration and severity of illness, and comorbidity. Future research needs to determine whether phenotypes predict treatment outcomes, and require different treatments." @default.
• W2221165617 created "2016-06-24" @default.
• W2221165617 creator A5000112259 @default.
• W2221165617 creator A5013574301 @default.
• W2221165617 creator A5014931039 @default.
• W2221165617 creator A5059881864 @default.
• W2221165617 creator A5082466887 @default.
• W2221165617 creator A5091332937 @default.
• W2221165617 date "2016-02-01" @default.
• W2221165617 modified "2023-09-30" @default.
• W2221165617 title "Chronic fatigue syndrome (CFS) symptom-based phenotypes in two clinical cohorts of adult patients in the UK and The Netherlands" @default.
• W2221165617 cites W1902123974 @default.
• W2221165617 cites W1965841147 @default.
• W2221165617 cites W197066864 @default.
• W2221165617 cites W1972071071 @default.
• W2221165617 cites W1977045331 @default.
• W2221165617 cites W1978144977 @default.
• W2221165617 cites W1979035382 @default.
• W2221165617 cites W1985186735 @default.
• W2221165617 cites W1989249467 @default.
• W2221165617 cites W1993700637 @default.
• W2221165617 cites W1999279831 @default.
• W2221165617 cites W2003263465 @default.
• W2221165617 cites W2007219090 @default.
• W2221165617 cites W2007887341 @default.
• W2221165617 cites W2013370609 @default.
• W2221165617 cites W2018030466 @default.
• W2221165617 cites W2018516812 @default.
• W2221165617 cites W2033315044 @default.
• W2221165617 cites W2064514539 @default.
• W2221165617 cites W2073807404 @default.
• W2221165617 cites W2080982097 @default.
• W2221165617 cites W2090330784 @default.
• W2221165617 cites W2097097572 @default.
• W2221165617 cites W2098287790 @default.
• W2221165617 cites W2105032143 @default.
• W2221165617 cites W2109088008 @default.
• W2221165617 cites W2112802342 @default.
• W2221165617 cites W2114414257 @default.
• W2221165617 cites W2117708629 @default.
• W2221165617 cites W2121060616 @default.
• W2221165617 cites W2125632037 @default.
• W2221165617 cites W2127807917 @default.
• W2221165617 cites W2130864428 @default.
• W2221165617 cites W2132536057 @default.
• W2221165617 cites W2134456714 @default.
• W2221165617 cites W2139008521 @default.
• W2221165617 cites W2141294075 @default.
• W2221165617 cites W2151404692 @default.
• W2221165617 cites W2155982386 @default.
• W2221165617 cites W2161407044 @default.
• W2221165617 cites W2167270466 @default.
• W2221165617 cites W2171234435 @default.
• W2221165617 cites W2171369299 @default.
• W2221165617 cites W2171701188 @default.
• W2221165617 cites W2172279241 @default.
• W2221165617 cites W2473786944 @default.
• W2221165617 cites W3143129303 @default.
• W2221165617 cites W4292806894 @default.
• W2221165617 cites W71792237 @default.
• W2221165617 doi "https://doi.org/10.1016/j.jpsychores.2015.12.006" @default.
• W2221165617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26800634" @default.
• W2221165617 hasPublicationYear "2016" @default.
• W2221165617 type Work @default.
• W2221165617 sameAs 2221165617 @default.
• W2221165617 citedByCount "44" @default.
• W2221165617 countsByYear W22211656172017 @default.
• W2221165617 countsByYear W22211656172018 @default.
• W2221165617 countsByYear W22211656172019 @default.
• W2221165617 countsByYear W22211656172020 @default.
• W2221165617 countsByYear W22211656172021 @default.
• W2221165617 countsByYear W22211656172022 @default.
• W2221165617 countsByYear W22211656172023 @default.
• W2221165617 crossrefType "journal-article" @default.
• W2221165617 hasAuthorship W2221165617A5000112259 @default.
• W2221165617 hasAuthorship W2221165617A5013574301 @default.
• W2221165617 hasAuthorship W2221165617A5014931039 @default.
• W2221165617 hasAuthorship W2221165617A5059881864 @default.
• W2221165617 hasAuthorship W2221165617A5082466887 @default.
• W2221165617 hasAuthorship W2221165617A5091332937 @default.
• W2221165617 hasBestOaLocation W22211656172 @default.
• W2221165617 hasConcept C105795698 @default.
• W2221165617 hasConcept C118552586 @default.
• W2221165617 hasConcept C126322002 @default.
• W2221165617 hasConcept C139719470 @default.
• W2221165617 hasConcept C141071460 @default.
• W2221165617 hasConcept C162324750 @default.
• W2221165617 hasConcept C1862650 @default.
• W2221165617 hasConcept C2776867660 @default.
• W2221165617 hasConcept C2777870961 @default.
• W2221165617 hasConcept C2779159551 @default.
• W2221165617 hasConcept C2779566273 @default.
• W2221165617 hasConcept C30036603 @default.
• W2221165617 hasConcept C33923547 @default.
• W2221165617 hasConcept C70727504 @default.
• W2221165617 hasConcept C71924100 @default.
• W2221165617 hasConceptScore W2221165617C105795698 @default.
• W2221165617 hasConceptScore W2221165617C118552586 @default.

• next