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- W2221307589 abstract "Toll-like receptors (TLR) are transmembrane pattern recognition receptors that recognize microbial ligands and signal for production of inflammatory cytokines and type I interferon in macrophages and dendritic cells (DC). Whereas TLR-induced inflammatory mediators are required for pathogen clearance, many are toxic to the host and can cause pathological inflammation when over-produced. This is demonstrated by the role of TLR-induced cytokines in autoimmune diseases, such as rheumatoid arthritis, inflammatory bowel disease, and systemic lupus erythematosus. Because of the potent effects of TLR-induced cytokines, we have diverse mechanisms to dampen TLR signaling. Here, we highlight three pathways that participate in inhibition of TLR responses in macrophages and DC, and their implications in autoimmunity; A20, encoded by the TNFAIP3 gene, Lyp encoded by the PTPN22 gene, and the BCAP/PI3K pathway. We present new findings that Lyp promotes TLR responses in primary human monocytes and that the autoimmunity risk Lyp620W variant is more effective at promoting TLR-induced interleukin-6 than the non-risk Lyp620R protein. This suggests that Lyp serves to downregulate a TLR inhibitory pathway in monocytes, and we propose that Lyp inhibits the TREM2/DAP12 inhibitory pathway. Overall, these pathways demonstrate distinct mechanisms of negative regulation of TLR responses, and all impact autoimmune disease pathogenesis and treatment." @default.
- W2221307589 created "2016-06-24" @default.
- W2221307589 creator A5014553224 @default.
- W2221307589 creator A5016439853 @default.
- W2221307589 creator A5019862484 @default.
- W2221307589 creator A5021144595 @default.
- W2221307589 creator A5026580610 @default.
- W2221307589 creator A5075685028 @default.
- W2221307589 date "2015-12-19" @default.
- W2221307589 modified "2023-10-18" @default.
- W2221307589 title "Negative regulation of TLR signaling in myeloid cells-implications for autoimmune diseases" @default.
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