Matches in SemOpenAlex for { <https://semopenalex.org/work/W2221429303> ?p ?o ?g. }
- W2221429303 abstract "The increased availability of whole genome sequences calls for quantitative models of global gene expression, yet predicting gene expression patterns directly from genome sequence remains a challenge. We examine the contributions of an individual regulator, the ferrous iron-responsive regulatory element, BqsR, on global patterns of gene expression in Pseudomonas aeruginosa. The position weight matrix (PWM) derived for BqsR uncovered hundreds of likely binding sites throughout the genome. Only a subset of these potential binding sites had a regulatory consequence, suggesting that BqsR/DNA interactions were not captured within the PWM or that the broader regulatory context at each promoter played a greater role in setting promoter outputs. The architecture of the BqsR operator was systematically varied to understand how binding site parameters influence expression. We found that BqsR operator affinity was predicted by the PWM well. At many promoters the surrounding regulatory context, including overlapping operators of BqsR or the presence of RhlR binding sites, were influential in setting promoter outputs. These results indicate more comprehensive models that include local regulatory contexts are needed to develop a predictive understanding of global regulatory outputs." @default.
- W2221429303 created "2016-06-24" @default.
- W2221429303 creator A5029612834 @default.
- W2221429303 creator A5065958736 @default.
- W2221429303 creator A5088184727 @default.
- W2221429303 creator A5090688813 @default.
- W2221429303 date "2015-12-17" @default.
- W2221429303 modified "2023-09-27" @default.
- W2221429303 title "Predicting the impact of promoter variability on regulatory outputs" @default.
- W2221429303 cites W1498410508 @default.
- W2221429303 cites W1548309673 @default.
- W2221429303 cites W1903655941 @default.
- W2221429303 cites W1950949146 @default.
- W2221429303 cites W1963949581 @default.
- W2221429303 cites W1970294462 @default.
- W2221429303 cites W1970986180 @default.
- W2221429303 cites W1973430111 @default.
- W2221429303 cites W1975992663 @default.
- W2221429303 cites W1980253661 @default.
- W2221429303 cites W1987591014 @default.
- W2221429303 cites W1999046178 @default.
- W2221429303 cites W1999073796 @default.
- W2221429303 cites W2003967338 @default.
- W2221429303 cites W2008047506 @default.
- W2221429303 cites W2010417142 @default.
- W2221429303 cites W2013449615 @default.
- W2221429303 cites W2017266538 @default.
- W2221429303 cites W2018645639 @default.
- W2221429303 cites W2021282293 @default.
- W2221429303 cites W2036122730 @default.
- W2221429303 cites W2038090714 @default.
- W2221429303 cites W2041382372 @default.
- W2221429303 cites W2044525257 @default.
- W2221429303 cites W2045362835 @default.
- W2221429303 cites W2054317879 @default.
- W2221429303 cites W2055016234 @default.
- W2221429303 cites W2056134018 @default.
- W2221429303 cites W2056707311 @default.
- W2221429303 cites W2064691604 @default.
- W2221429303 cites W2066846401 @default.
- W2221429303 cites W2071735418 @default.
- W2221429303 cites W2074675420 @default.
- W2221429303 cites W2078470194 @default.
- W2221429303 cites W2087177706 @default.
- W2221429303 cites W2091913250 @default.
- W2221429303 cites W2092808125 @default.
- W2221429303 cites W2097483034 @default.
- W2221429303 cites W2100199965 @default.
- W2221429303 cites W2108316907 @default.
- W2221429303 cites W2109711276 @default.
- W2221429303 cites W2110035347 @default.
- W2221429303 cites W2114562795 @default.
- W2221429303 cites W2116634411 @default.
- W2221429303 cites W2116696234 @default.
- W2221429303 cites W2119406110 @default.
- W2221429303 cites W2122202426 @default.
- W2221429303 cites W2126918333 @default.
- W2221429303 cites W2127539199 @default.
- W2221429303 cites W2129149800 @default.
- W2221429303 cites W2129375421 @default.
- W2221429303 cites W2131417813 @default.
- W2221429303 cites W2131946590 @default.
- W2221429303 cites W2135034797 @default.
- W2221429303 cites W2142691347 @default.
- W2221429303 cites W2146292204 @default.
- W2221429303 cites W2147339635 @default.
- W2221429303 cites W2148998200 @default.
- W2221429303 cites W2154107723 @default.
- W2221429303 cites W2157009395 @default.
- W2221429303 cites W2158752832 @default.
- W2221429303 cites W2159933659 @default.
- W2221429303 cites W2162773926 @default.
- W2221429303 cites W2168013784 @default.
- W2221429303 cites W2170806980 @default.
- W2221429303 cites W2171527366 @default.
- W2221429303 cites W2952401836 @default.
- W2221429303 cites W3100113366 @default.
- W2221429303 doi "https://doi.org/10.1038/srep18238" @default.
- W2221429303 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4682146" @default.
- W2221429303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26675057" @default.
- W2221429303 hasPublicationYear "2015" @default.
- W2221429303 type Work @default.
- W2221429303 sameAs 2221429303 @default.
- W2221429303 citedByCount "8" @default.
- W2221429303 countsByYear W22214293032017 @default.
- W2221429303 countsByYear W22214293032018 @default.
- W2221429303 countsByYear W22214293032019 @default.
- W2221429303 countsByYear W22214293032020 @default.
- W2221429303 countsByYear W22214293032023 @default.
- W2221429303 crossrefType "journal-article" @default.
- W2221429303 hasAuthorship W2221429303A5029612834 @default.
- W2221429303 hasAuthorship W2221429303A5065958736 @default.
- W2221429303 hasAuthorship W2221429303A5088184727 @default.
- W2221429303 hasAuthorship W2221429303A5090688813 @default.
- W2221429303 hasBestOaLocation W22214293031 @default.
- W2221429303 hasConcept C101762097 @default.
- W2221429303 hasConcept C104317684 @default.
- W2221429303 hasConcept C141231307 @default.
- W2221429303 hasConcept C150194340 @default.
- W2221429303 hasConcept C151730666 @default.