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- W2221460900 abstract "Objective: Postpartum hemorrhage (PPH) is a major cause of maternal deathover theworld. Atonic bleeding is themost frequent case of PPH, however, the pathophysiology has not been clarified. Particularly in Japan, we currently assume these conditions as clinical amniotic fluid embolism. In the present study, we analyzed pathological changes and identified immune cells in myometrium in PPH of unknown etiology. Methods: Myometrium tissues were from 34 cases of PPH of unknown etiology, 15 cases of control pregnant women and 18 cases after delivery women without PPH. HE, Alcian Blue and immunohistochemical stainings with anti-C5a receptor, anti-mast cell tryptase, anti-neutrophil elastase, anti-CD68, anti-CD3, and anti-ZnCP1 antibodies were performed to count positive stained cells. The Ethics Committee of Hamamatsu University School of Medicine approved all the procedures of this study. Results: Myometrium from PPH presented stromal edema infiltrated with immune cells and C5aR positive cells. Mast cells, neutrophil and macrophage were significantly increased in myometrium in PPH but not in controls. T cells were not present in all subjects. ZnCP1 were positive in the 70% of PPH cases. Conclusion: Myometrium edema due to postpartum acute myometritis in the absence of an infective etiology may be a histological characteristic of PPH of unknown etiology." @default.
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- W2221460900 date "2015-11-01" @default.
- W2221460900 modified "2023-09-27" @default.
- W2221460900 title "Postpartum acute myometritis as a pathological feature in postpartum hemorrhage of unknown etiology" @default.
- W2221460900 doi "https://doi.org/10.1016/j.jri.2015.09.008" @default.
- W2221460900 hasPublicationYear "2015" @default.
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