FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2221527623> ?p ?o ?g. }

• W2221527623 endingPage "9" @default.
• W2221527623 startingPage "1" @default.
• W2221527623 abstract "The purpose of the current study was to evaluate the influences of nornicotine and nicotine (NT) in cigarette smoke on the expression of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) in retinal pigment epithelium cells and human umbilical vein endothelial cells (HUVECs). Furthermore, the angiogenic behaviors of endothelial cells under nornicotine and NT treatment were assessed by using in vitro methods.ARPE-19 cells and HUVECs were treated with different concentrations of either nornicotine or NT for different periods of time. The cell proliferative effect was investigated by using the method of MTT analysis. HUVEC migration and tube formation were assessed by using the scratch assay and Matrigel models. The expressions of VEGF and PEDF gene and protein in both types of cells were examined by real-time RT-PCR and Western blot.There was no proliferation of ARPE-19 cells following treatment with various concentrations of nornicotine or NT. In contrast, nornicotine or NT significantly stimulated HUVEC proliferation, migration and tube formation. Nornicotine and NT upregulated the expression of VEGF but suppressed the expression of PEDF at both mRNA and protein levels in a dose- and time-dependent manner in ARPE-19 cells and HUVECs.Our results demonstrate that nornicotine and NT promoted endothelial cellular proliferation, migration and tube formation of HUVECs in vitro. These effects might be partly due to simultaneous modulation of VEGF/PEDF signaling in ARPE-19 cells and HUVECs." @default.
• W2221527623 created "2016-06-24" @default.
• W2221527623 creator A5019074556 @default.
• W2221527623 creator A5040215906 @default.
• W2221527623 creator A5065594717 @default.
• W2221527623 creator A5079527792 @default.
• W2221527623 date "2015-11-05" @default.
• W2221527623 modified "2023-09-27" @default.
• W2221527623 title "Nornicotine and Nicotine Induced Neovascularization via Increased VEGF/PEDF Ratio" @default.
• W2221527623 cites W180812339 @default.
• W2221527623 cites W1965547271 @default.
• W2221527623 cites W1966367482 @default.
• W2221527623 cites W1966816241 @default.
• W2221527623 cites W1975302822 @default.
• W2221527623 cites W1977485556 @default.
• W2221527623 cites W1990289864 @default.
• W2221527623 cites W1994451872 @default.
• W2221527623 cites W2002407951 @default.
• W2221527623 cites W2017035172 @default.
• W2221527623 cites W2029604699 @default.
• W2221527623 cites W2047415412 @default.
• W2221527623 cites W2065024025 @default.
• W2221527623 cites W2066156389 @default.
• W2221527623 cites W2080306860 @default.
• W2221527623 cites W2082650018 @default.
• W2221527623 cites W2086359365 @default.
• W2221527623 cites W2088749707 @default.
• W2221527623 cites W2088923778 @default.
• W2221527623 cites W2123921337 @default.
• W2221527623 cites W2133586479 @default.
• W2221527623 cites W2135554005 @default.
• W2221527623 cites W2147886123 @default.
• W2221527623 cites W2151056029 @default.
• W2221527623 cites W2167243909 @default.
• W2221527623 cites W4247214019 @default.
• W2221527623 cites W4255450278 @default.
• W2221527623 doi "https://doi.org/10.1159/000440847" @default.
• W2221527623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26536586" @default.
• W2221527623 hasPublicationYear "2015" @default.
• W2221527623 type Work @default.
• W2221527623 sameAs 2221527623 @default.
• W2221527623 citedByCount "11" @default.
• W2221527623 countsByYear W22215276232016 @default.
• W2221527623 countsByYear W22215276232018 @default.
• W2221527623 countsByYear W22215276232019 @default.
• W2221527623 countsByYear W22215276232020 @default.
• W2221527623 countsByYear W22215276232021 @default.
• W2221527623 countsByYear W22215276232023 @default.
• W2221527623 crossrefType "journal-article" @default.
• W2221527623 hasAuthorship W2221527623A5019074556 @default.
• W2221527623 hasAuthorship W2221527623A5040215906 @default.
• W2221527623 hasAuthorship W2221527623A5065594717 @default.
• W2221527623 hasAuthorship W2221527623A5079527792 @default.
• W2221527623 hasConcept C123012128 @default.
• W2221527623 hasConcept C126322002 @default.
• W2221527623 hasConcept C153911025 @default.
• W2221527623 hasConcept C16685009 @default.
• W2221527623 hasConcept C167734588 @default.
• W2221527623 hasConcept C185592680 @default.
• W2221527623 hasConcept C202751555 @default.
• W2221527623 hasConcept C2776166849 @default.
• W2221527623 hasConcept C2777025900 @default.
• W2221527623 hasConcept C2777411675 @default.
• W2221527623 hasConcept C2778024200 @default.
• W2221527623 hasConcept C2778608917 @default.
• W2221527623 hasConcept C2779547902 @default.
• W2221527623 hasConcept C2780394083 @default.
• W2221527623 hasConcept C2780783641 @default.
• W2221527623 hasConcept C2780827179 @default.
• W2221527623 hasConcept C502942594 @default.
• W2221527623 hasConcept C52237779 @default.
• W2221527623 hasConcept C55493867 @default.
• W2221527623 hasConcept C62112901 @default.
• W2221527623 hasConcept C71924100 @default.
• W2221527623 hasConcept C86803240 @default.
• W2221527623 hasConcept C95444343 @default.
• W2221527623 hasConceptScore W2221527623C123012128 @default.
• W2221527623 hasConceptScore W2221527623C126322002 @default.
• W2221527623 hasConceptScore W2221527623C153911025 @default.
• W2221527623 hasConceptScore W2221527623C16685009 @default.
• W2221527623 hasConceptScore W2221527623C167734588 @default.
• W2221527623 hasConceptScore W2221527623C185592680 @default.
• W2221527623 hasConceptScore W2221527623C202751555 @default.
• W2221527623 hasConceptScore W2221527623C2776166849 @default.
• W2221527623 hasConceptScore W2221527623C2777025900 @default.
• W2221527623 hasConceptScore W2221527623C2777411675 @default.
• W2221527623 hasConceptScore W2221527623C2778024200 @default.
• W2221527623 hasConceptScore W2221527623C2778608917 @default.
• W2221527623 hasConceptScore W2221527623C2779547902 @default.
• W2221527623 hasConceptScore W2221527623C2780394083 @default.
• W2221527623 hasConceptScore W2221527623C2780783641 @default.
• W2221527623 hasConceptScore W2221527623C2780827179 @default.
• W2221527623 hasConceptScore W2221527623C502942594 @default.
• W2221527623 hasConceptScore W2221527623C52237779 @default.
• W2221527623 hasConceptScore W2221527623C55493867 @default.
• W2221527623 hasConceptScore W2221527623C62112901 @default.
• W2221527623 hasConceptScore W2221527623C71924100 @default.
• W2221527623 hasConceptScore W2221527623C86803240 @default.

• next