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- W2221569364 abstract "Publisher Summary This chapter describes some recent investigations of the distribution and effects of two classes of organic cations, basic dyes and tetrazolium salts in the central nervous system. These agents exhibit interesting but divergent neurobiological behavior which depends in part upon their selective affinity for different cytoplasmic organelles. Basic dyes accumulate mainly within lysosomes and cause remarkable but reversible changes in the structure of these particles without altering their function. Tetrazoles, on the other hand, concentrate within mitochondria, undergo reduction to the insoluble formazan derivatives and cause serious disruption of mitochondria1 structure and function. The physiological effects, the intracellular localization and the mechanism of vital metachromasia of lysosomes by cationic dyes are mentioned in the paper. The results were obtained by Electron microscopic observations and biochemical studies. As a conclusion, the chapter puts forward the result that Lamellar structures have been found in lysosomes in diverse circumstances, for example, in macrophages after uptake of India ink, in liver cells incorporating bile pigment and kidney tubule cells after uptake of trypan blue and thorium dioxide. Similar experiments were conducted for Tetrazolium salts. The selective localization of formazan deposits within mitochondria in viva depends upon the combined presence of electron donors generated during oxidative phosphorylation and the appropriate dehydrogenases. The resultant mitochondria1 swelling indicates an accumulation of osmotically active particles within the mitochondria1 cavity." @default.
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- W2221569364 date "1968-01-01" @default.
- W2221569364 modified "2023-09-27" @default.
- W2221569364 title "Transport and Effects of Cationic Dyes and Tetrazolium Salts in the Central Nervous System" @default.
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- W2221569364 doi "https://doi.org/10.1016/s0079-6123(08)64150-3" @default.
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