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• W2221569376 abstract "We have examined the contribution of L-type Ca 2+ current ( I Ca ) to the activation of contraction in trout atrial myocytes under basal and phosphorylating conditions. The average myocyte length was 197 ± 14 μm, width was 5.5 ± 0.2 μm, and cell capacitance was 36.2 ± 2.2 pF. With 25 μM EGTA in the patch pipette and a stimulation frequency of 0.125 Hz, I Ca was 2.6 ± 0.4 pA/pF and it carried a total charge of 0.10 ± 0.01 pC/pF, giving rise to a contraction of 15.2 ± 2.8% of the resting cell length. With a cell volume of 2.4 ± 0.3 pl, the charge carried by I Ca corresponded to 14.7 ± 2.2 μmol Ca 2+ /l nonmitochondrial cell volume (μM). This can account for only 30–40% of the Ca 2+ binding to the myofilaments during a contraction. Increasing the stimulation frequency from 0.25 to 2 Hz decreased I Ca amplitude and charge by 66 ± 5 and 80 ± 3%, respectively. Elevating the pipette EGTA concentration from 25 μM to 5 mM increased I Ca amplitude and charge by ∼290%. Both isoproterenol and cAMP increased I Ca by ∼230%. The total charge carried by the isoproterenol- or cAMP-stimulated current was increased by 170%. We conclude that the use of high-EGTA concentration may overestimate the total Ca 2+ carried by I Ca under physiological conditions. Furthermore, the results suggest that, in contrast to previous reports from other lower vertebrates, Ca 2+ flux through L-type Ca 2+ channels alone is not sufficient to fully activate contraction in trout atrial myocytes at room temperature." @default.
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• W2221569376 date "1998-12-01" @default.
• W2221569376 modified "2023-09-25" @default.
• W2221569376 title "L-type Ca²⁺current and excitation-contraction coupling in single atrial myocytes from rainbow trout" @default.
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• W2221569376 doi "https://doi.org/10.1152/ajpregu.1998.275.6.r2061" @default.
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