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- W2221622265 abstract "Evidence regarding the use of bortezomib-containing schemes in primary treatment of antibody-mediated rejection in heart transplant recipients is scarce. This case report presents the clinical experience with upstream use of bortezomib in primary treatment of early antibody-mediated rejection in an adult heart transplant recipient. Two cycles of bortezomib together with methylprednisolone, immunoadsorption, rituximab, and supplementary doses of intravenous immunoglobulin G reversed signs of heart failure, production of donor-specific antibodies, and findings of antibody-mediated rejection in biopsy. This treatment regimen was tolerated with only mild hematologic toxicity and proved to be successful during a 12-month follow-up. Primary treatment with a bortezomib-containing regimen appears to be a new therapeutic option for severe antibody-mediated rejection in heart transplant recipients. However, the efficacy and safety of this treatment need to be tested in prospective trials." @default.
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- W2221622265 date "2015-06-01" @default.
- W2221622265 modified "2023-10-14" @default.
- W2221622265 title "Bortezomib-Containing Regimen for Primary Treatment of Early Antibody-Mediated Cardiac Allograft Rejection: A Case Report" @default.
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- W2221622265 doi "https://doi.org/10.7182/pit2015934" @default.
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