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- W2221773054 abstract "Indirubin is the active ingredient of Danggui Longhui Wan, a mixture of plants that is used in traditional Chinese medicine to treat chronic diseases. In this study we investigated the anti-inflammatory effects of an indirubin derivative, indirubin-3'-monoxime-5-sulphonic acid (I3M-5S, C 16 H 11 N 3 O 5 S). We found that I3M-5S inhibits the production of various inflammatory mediators such as nitric oxide (NO) and prostaglandin E 2 (PGE 2 ) as well as inflammatory cytokines, tumor necrosis factor-α and interleukin-6 in lipopolysaccharide (LPS) stimulated murine macrophage, RAW264.7 cells. In addition, the expression of inducible nitric oxide synthase and cyclooxygenase-2, which are essential enzymes to produce NO and PGE 2 , respectively, was blocked by I3M-5S treatment in LPS-stimulated RAW264.7 cells. Present data suggest that I3M-5S exhibits potent anti-inflammatory activity in cultured macrophages and merit further study as potential therapeutic agents for inflammatory disorders." @default.
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- W2221773054 date "2011-09-01" @default.
- W2221773054 modified "2023-09-27" @default.
- W2221773054 title "Anti-inflammatory Effect of Indirubin-3'-Monoxime-5-Sulphonic Acid on Lipopolysaccharide-stimulated Murine Macrophage" @default.
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