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• W2222041118 abstract "In silico dissection of crotalicidin (Ctn), a cathelicidin from a South American pit viper, yielded fragments Ctn[1–14] and Ctn[15–34], which were tested to ascertain to what extent they reproduced the structure and activity of the parent peptide. NMR data showing Ctn to be α-helical at the N-terminus and unstructured at the C-terminus were matched by similar data from the fragments. The peptides were tested against Gram-positive and -negative bacteria and for toxicity against both tumor and healthy cells. Despite its amphipathic α-helical structure, Ctn[1–14] was totally inert toward bacteria or eukaryotic cells. In contrast, unstructured Ctn[15–34] replicated the activity of parent Ctn against Gram-negative bacteria and tumor cells while being significantly less toxic toward eukaryotic cells. This selectivity for bacteria and tumor cells, plus a stability to serum well above that of Ctn, portrays Ctn[15–34] as an appealing candidate for further development as an anti-infective or antitumor lead." @default.
• W2222041118 created "2016-06-24" @default.
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• W2222041118 date "2015-10-26" @default.
• W2222041118 modified "2023-10-16" @default.
• W2222041118 title "Structural Dissection of Crotalicidin, a Rattlesnake Venom Cathelicidin, Retrieves a Fragment with Antimicrobial and Antitumor Activity" @default.
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• W2222041118 doi "https://doi.org/10.1021/acs.jmedchem.5b01142" @default.
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