FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2222095243> ?p ?o ?g. }

• W2222095243 endingPage "789" @default.
• W2222095243 startingPage "782" @default.
• W2222095243 abstract "ABSTRACT Interleukin 22 (IL-22) is an IL-10-related cytokine produced by T helper 17 (Th17) cells and other immune cells that signals via IL-22 receptor alpha 1 (IL-22Ra1), which is expressed on epithelial tissues, as well as hepatocytes. IL-22 has been shown to have hepatoprotective effects that are mediated by signal transducer and activator of transcription 3 (STAT3) signaling. However, it is unclear whether IL-22 can directly regulate antimicrobial programs in the liver. To test this hypothesis, hepatocyte-specific IL-22Ra1 knockout ( Il22Ra1 Hep−/− ) and Stat3 knockout ( Stat3 Hep −/− ) mice were generated and subjected to intra-abdominal infection with Klebsiella pneumoniae , which results in liver injury and necrosis. We found that overexpression of IL-22 or therapeutic administration of recombinant IL-22 (rIL-22), given 2 h postinfection, significantly reduced the bacterial burden in both the liver and spleen. The antimicrobial activity of rIL-22 required hepatic Il22Ra1 and Stat3 . Serum from rIL-22-treated mice showed potent bacteriostatic activity against K. pneumoniae , which was dependent on lipocalin 2 (LCN2). However, in vivo , rIL-22-induced antimicrobial activity was only partially reduced in LCN2-deficient mice. We found that rIL-22 also induced serum amyloid A2 (SAA2) and that SAA2 had anti- K. pneumoniae bactericidal activity in vitro . These results demonstrate that IL-22, through IL-22Ra1 and STAT3 singling, can induce intrinsic antimicrobial activity in the liver, which is due in part to LCN2 and SAA2. Therefore, IL-22 may be a useful adjunct in treating hepatic and intra-abdominal infections." @default.
• W2222095243 created "2016-06-24" @default.
• W2222095243 creator A5010937426 @default.
• W2222095243 creator A5021846790 @default.
• W2222095243 creator A5041622853 @default.
• W2222095243 creator A5050713158 @default.
• W2222095243 creator A5053138445 @default.
• W2222095243 creator A5063111442 @default.
• W2222095243 creator A5077287945 @default.
• W2222095243 creator A5086523387 @default.
• W2222095243 date "2016-03-01" @default.
• W2222095243 modified "2023-10-13" @default.
• W2222095243 title "Therapeutic Role of Interleukin 22 in Experimental Intra-abdominal Klebsiella pneumoniae Infection in Mice" @default.
• W2222095243 cites W1610022685 @default.
• W2222095243 cites W1791863657 @default.
• W2222095243 cites W1864605302 @default.
• W2222095243 cites W1964052073 @default.
• W2222095243 cites W1965301687 @default.
• W2222095243 cites W1972140301 @default.
• W2222095243 cites W1982229304 @default.
• W2222095243 cites W1989787732 @default.
• W2222095243 cites W1993757198 @default.
• W2222095243 cites W1997959054 @default.
• W2222095243 cites W2004650652 @default.
• W2222095243 cites W2006338438 @default.
• W2222095243 cites W2007121925 @default.
• W2222095243 cites W2020893478 @default.
• W2222095243 cites W2040736784 @default.
• W2222095243 cites W2043529001 @default.
• W2222095243 cites W2044171889 @default.
• W2222095243 cites W2054744363 @default.
• W2222095243 cites W2062564526 @default.
• W2222095243 cites W2065590798 @default.
• W2222095243 cites W2079241145 @default.
• W2222095243 cites W2082159115 @default.
• W2222095243 cites W2083764107 @default.
• W2222095243 cites W2086757562 @default.
• W2222095243 cites W2091845172 @default.
• W2222095243 cites W2096556320 @default.
• W2222095243 cites W2098855274 @default.
• W2222095243 cites W2106464597 @default.
• W2222095243 cites W2107066107 @default.
• W2222095243 cites W2129235766 @default.
• W2222095243 cites W2135484088 @default.
• W2222095243 cites W2136279532 @default.
• W2222095243 cites W2148920499 @default.
• W2222095243 cites W2149717861 @default.
• W2222095243 cites W2156067216 @default.
• W2222095243 doi "https://doi.org/10.1128/iai.01268-15" @default.
• W2222095243 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4771339" @default.
• W2222095243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26729763" @default.
• W2222095243 hasPublicationYear "2016" @default.
• W2222095243 type Work @default.
• W2222095243 sameAs 2222095243 @default.
• W2222095243 citedByCount "34" @default.
• W2222095243 countsByYear W22220952432016 @default.
• W2222095243 countsByYear W22220952432017 @default.
• W2222095243 countsByYear W22220952432018 @default.
• W2222095243 countsByYear W22220952432019 @default.
• W2222095243 countsByYear W22220952432020 @default.
• W2222095243 countsByYear W22220952432021 @default.
• W2222095243 countsByYear W22220952432022 @default.
• W2222095243 countsByYear W22220952432023 @default.
• W2222095243 crossrefType "journal-article" @default.
• W2222095243 hasAuthorship W2222095243A5010937426 @default.
• W2222095243 hasAuthorship W2222095243A5021846790 @default.
• W2222095243 hasAuthorship W2222095243A5041622853 @default.
• W2222095243 hasAuthorship W2222095243A5050713158 @default.
• W2222095243 hasAuthorship W2222095243A5053138445 @default.
• W2222095243 hasAuthorship W2222095243A5063111442 @default.
• W2222095243 hasAuthorship W2222095243A5077287945 @default.
• W2222095243 hasAuthorship W2222095243A5086523387 @default.
• W2222095243 hasBestOaLocation W22220952431 @default.
• W2222095243 hasConcept C104317684 @default.
• W2222095243 hasConcept C150903083 @default.
• W2222095243 hasConcept C171958077 @default.
• W2222095243 hasConcept C203014093 @default.
• W2222095243 hasConcept C207001950 @default.
• W2222095243 hasConcept C2777058267 @default.
• W2222095243 hasConcept C2778690821 @default.
• W2222095243 hasConcept C2778923194 @default.
• W2222095243 hasConcept C50345908 @default.
• W2222095243 hasConcept C547475151 @default.
• W2222095243 hasConcept C55493867 @default.
• W2222095243 hasConcept C62478195 @default.
• W2222095243 hasConcept C74172505 @default.
• W2222095243 hasConcept C86803240 @default.
• W2222095243 hasConcept C8891405 @default.
• W2222095243 hasConcept C89423630 @default.
• W2222095243 hasConceptScore W2222095243C104317684 @default.
• W2222095243 hasConceptScore W2222095243C150903083 @default.
• W2222095243 hasConceptScore W2222095243C171958077 @default.
• W2222095243 hasConceptScore W2222095243C203014093 @default.
• W2222095243 hasConceptScore W2222095243C207001950 @default.
• W2222095243 hasConceptScore W2222095243C2777058267 @default.
• W2222095243 hasConceptScore W2222095243C2778690821 @default.
• W2222095243 hasConceptScore W2222095243C2778923194 @default.
• W2222095243 hasConceptScore W2222095243C50345908 @default.

• next