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• W2222352020 abstract "Purpose To demonstrate the feasibility of imaging a bolus of co-polarized [1-13C]pyruvate and 13C-urea to simultaneously assess both metabolism and perfusion in the rodent heart. Methods Copolarized [1-13C]pyruvate and 13C-urea was imaged using a multi-echo, flow-sensitized spiral pulse sequence. Healthy rats were scanned in a two-factor factorial design (n = 12 total; metabolism: overnight fasting versus fed with dichloroacetate injection; perfusion: rest versus adenosine stress-induced hyperemia). Results Alterations in metabolism were detected by changes in pyruvate metabolism into 13C-bicarbonate. Statistically independent alterations in perfusion were detected by changes in myocardial pyruvate and urea signals. Conclusion The new pulse sequence was used to obtain maps of metabolism and perfusion in the rodent heart in a single acquisition. This hyperpolarized 13C imaging test is expected to enable new studies in which the cardiac metabolism/perfusion mismatch can be studied in the acute environment. Magn Reson Med 77:151–158, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine" @default.
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• W2222352020 date "2016-01-07" @default.
• W2222352020 modified "2023-10-02" @default.
• W2222352020 title "Simultaneous assessment of cardiac metabolism and perfusion using copolarized [1‐ ¹³ C]pyruvate and ¹³ C‐urea" @default.
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• W2222352020 doi "https://doi.org/10.1002/mrm.26106" @default.
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