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- W2222412492 endingPage "105" @default.
- W2222412492 startingPage "96" @default.
- W2222412492 abstract "Bone tissue engineering is a promising therapeutic alternative for bone grafting of large skeletal defects. It generally comprises an ex vivo engineered combination of a carrier structure, stem/progenitor cells and growth factors. However, the success of these regenerative implants largely depends on how well implanted cells will adapt to the hostile and hypoxic host environment they encounter after implantation. In this review, we will discuss how hypoxia signalling may be used to improve bone regeneration in a tissue-engineered construct. First, hypoxia signalling induces angiogenesis which increases the survival of the implanted cells as well as stimulates bone formation. Second, hypoxia signalling has also angiogenesis-independent effects on mesenchymal cells in vitro, offering exciting new possibilities to improve tissue-engineered bone regeneration in vivo. In addition, studies in other fields have shown that benefits of modulating hypoxia signalling include enhanced cell survival, proliferation and differentiation, culminating in a more potent regenerative implant. Finally, the stimulation of endochondral bone formation as a physiological pathway to circumvent the harmful effects of hypoxia will be briefly touched upon. Thus, angiogenic dependent and independent processes may counteract the deleterious hypoxic effects and we will discuss several therapeutic strategies that may be combined to withstand the hypoxia upon implantation and improve bone regeneration." @default.
- W2222412492 created "2016-06-24" @default.
- W2222412492 creator A5046622164 @default.
- W2222412492 creator A5077350979 @default.
- W2222412492 creator A5088813832 @default.
- W2222412492 date "2016-09-01" @default.
- W2222412492 modified "2023-10-16" @default.
- W2222412492 title "Targeting the hypoxic response in bone tissue engineering: A balance between supply and consumption to improve bone regeneration" @default.
- W2222412492 cites W1448587601 @default.
- W2222412492 cites W1484579780 @default.
- W2222412492 cites W1502442150 @default.
- W2222412492 cites W1546919480 @default.
- W2222412492 cites W1563033895 @default.
- W2222412492 cites W1572866790 @default.
- W2222412492 cites W1596539624 @default.
- W2222412492 cites W1655121423 @default.
- W2222412492 cites W1749022239 @default.
- W2222412492 cites W1797652360 @default.
- W2222412492 cites W1891249103 @default.
- W2222412492 cites W1901024722 @default.
- W2222412492 cites W1924771079 @default.
- W2222412492 cites W1964793085 @default.
- W2222412492 cites W1967194906 @default.
- W2222412492 cites W1967212422 @default.
- W2222412492 cites W1972461209 @default.
- W2222412492 cites W1973293639 @default.
- W2222412492 cites W1973994630 @default.
- W2222412492 cites W1975554070 @default.
- W2222412492 cites W1976550852 @default.
- W2222412492 cites W1978047251 @default.
- W2222412492 cites W1985111027 @default.
- W2222412492 cites W1985367412 @default.
- W2222412492 cites W1988582362 @default.
- W2222412492 cites W1990517924 @default.
- W2222412492 cites W1991586090 @default.
- W2222412492 cites W2001380203 @default.
- W2222412492 cites W2002967048 @default.
- W2222412492 cites W2008943389 @default.
- W2222412492 cites W2009621718 @default.
- W2222412492 cites W2010296156 @default.
- W2222412492 cites W2011317126 @default.
- W2222412492 cites W2013564442 @default.
- W2222412492 cites W2015136076 @default.
- W2222412492 cites W2016160962 @default.
- W2222412492 cites W2017482231 @default.
- W2222412492 cites W2017575850 @default.
- W2222412492 cites W2018459010 @default.
- W2222412492 cites W2021773986 @default.
- W2222412492 cites W2027942070 @default.
- W2222412492 cites W2030620101 @default.
- W2222412492 cites W2031998606 @default.
- W2222412492 cites W2037690890 @default.
- W2222412492 cites W2038607522 @default.
- W2222412492 cites W2040099855 @default.
- W2222412492 cites W2041052781 @default.
- W2222412492 cites W2042221627 @default.
- W2222412492 cites W2044322920 @default.
- W2222412492 cites W2047305865 @default.
- W2222412492 cites W2048539785 @default.
- W2222412492 cites W2049140373 @default.
- W2222412492 cites W2050572533 @default.
- W2222412492 cites W2052454749 @default.
- W2222412492 cites W2052520062 @default.
- W2222412492 cites W2054719244 @default.
- W2222412492 cites W2055200656 @default.
- W2222412492 cites W2058992881 @default.
- W2222412492 cites W2059756376 @default.
- W2222412492 cites W2060113755 @default.
- W2222412492 cites W2060424229 @default.
- W2222412492 cites W2060959662 @default.
- W2222412492 cites W2063776845 @default.
- W2222412492 cites W2065533441 @default.
- W2222412492 cites W2065706780 @default.
- W2222412492 cites W2066549760 @default.
- W2222412492 cites W2069641472 @default.
- W2222412492 cites W2071227792 @default.
- W2222412492 cites W2074597140 @default.
- W2222412492 cites W2075054245 @default.
- W2222412492 cites W2075282047 @default.
- W2222412492 cites W2079837524 @default.
- W2222412492 cites W2080727542 @default.
- W2222412492 cites W2081501418 @default.
- W2222412492 cites W2083500461 @default.
- W2222412492 cites W2084902893 @default.
- W2222412492 cites W2087308788 @default.
- W2222412492 cites W2087414338 @default.
- W2222412492 cites W2089004231 @default.
- W2222412492 cites W2089866145 @default.
- W2222412492 cites W2092782728 @default.
- W2222412492 cites W2093014461 @default.
- W2222412492 cites W2093726173 @default.
- W2222412492 cites W2094320187 @default.
- W2222412492 cites W2099397203 @default.
- W2222412492 cites W2099667514 @default.
- W2222412492 cites W2101084498 @default.
- W2222412492 cites W2103492381 @default.
- W2222412492 cites W2104272971 @default.
- W2222412492 cites W2108358002 @default.